ID J9VUL8_CRYNH Unreviewed; 752 AA.
AC J9VUL8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Peptidase {ECO:0000313|EMBL:AFR97111.2};
GN ORFNames=CNAG_04380 {ECO:0000313|EMBL:AFR97111.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR97111.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR97111.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; CP003828; AFR97111.2; -; Genomic_DNA.
DR RefSeq; XP_012051512.1; XM_012196122.1.
DR AlphaFoldDB; J9VUL8; -.
DR GeneID; 23887815; -.
DR KEGG; cng:CNAG_04380; -.
DR VEuPathDB; FungiDB:CNAG_04380; -.
DR OrthoDB; 1696312at2759; -.
DR Proteomes; UP000010091; Chromosome 9.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF89; SACCHAROPEPSIN; 1.
DR Pfam; PF00026; Asp; 2.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..752
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003828886"
FT DOMAIN 119..608
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 26..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..68
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 752 AA; 78111 MW; 041BC1BB276B966B CRC64;
MVNAHILTVL SILPLSLATL PEPDPHNGLS LEPAPAARQV TDTSVRPVKH DRGHGKQPIR
KASARKRSAK RTPTAAATPF VGVGGIELDL VERENTNRGM VKRWDNGTLL PLGTSQNTFV
VPVSIGSPPT TYPLQLDLAS SDILLASTLC GSHCPTSLGT TTNPYYDVSK PSAGFESINS
NQTVWNTSYA DGTVASGFLA REIITLGQSV VQGQVFGMIN ATNLTLSSQK SSGILGLGFP
RLSTLAHVLF EEQHEQASTI ASTSSSSSSV NGTTSTSVST LSNATGIMSA STASASGPTY
LPTLLENLVR TPHLPYPVFA LALSAPIKSS SSSSSSSAAA SASSRYKPSI GSLTLGGLSS
YYVDDTAGSG RTVGDIEWHD VVPFGQPVSA ANGTATTEEQ AVTTSASGGT LSASSTSENS
TEEEAVSASS TFNNTARKRS DESQLDAFPS TVSELSQEEY LYWALDLQNV TVNGTDVGIN
SSYASIGLGS VALLDAGFNG IAGPQQDVVN LFRLITDARK VSEGQWAVPC NTRMTLGFSF
GGKYIQLQPS DWIYAGIAQS TMCLAWPIAQ PATGDGIDWQ LGTPFLKNVY TIFSYGINGK
QAPLVGFLPL ESTTVANNST GDNTAADRNS PTPTSIAALS LTTTLRTALP NAVLPDPTFP
TPTYAYSATP SLLQPGAPQY LGLANGSAYE VMDVPVISVD KSAVSSIAIG NNGGGSNVSD
GPSSAAPRRM NTESVAGMGM MVIGMMVGVV MV
//