ID J9VX58_CRYNH Unreviewed; 520 AA.
AC J9VX58;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 22-FEB-2023, entry version 38.
DE RecName: Full=Fe2OG dioxygenase domain-containing protein {ECO:0000259|PROSITE:PS51471};
GN ORFNames=CNAG_05612 {ECO:0000313|EMBL:AFR99042.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR99042.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR99042.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003833; AFR99042.2; -; Genomic_DNA.
DR RefSeq; XP_012053675.1; XM_012198285.1.
DR AlphaFoldDB; J9VX58; -.
DR GeneID; 23888911; -.
DR KEGG; cng:CNAG_05612; -.
DR VEuPathDB; FungiDB:CNAG_05612; -.
DR HOGENOM; CLU_026011_2_0_1; -.
DR OrthoDB; 325143at2759; -.
DR Proteomes; UP000010091; Chromosome 14.
DR GO; GO:0051213; F:dioxygenase activity; IEA:InterPro.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:InterPro.
DR GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IEA:InterPro.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032854; ALKBH3.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR31212; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR PANTHER; PTHR31212:SF4; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
FT DOMAIN 290..418
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 61..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 56502 MW; F3D4D389F2A4313D CRC64;
MLSNADASIN FNANTSNEEE LDTETKLVLL ASLIHPLALP PQALEVLASV DGDVAKAAEK
LSLPSPETPR KRKAGSSLQG WLGCPGDSKR AVKAKGKQEA ESTDRHLTLS AAGGSKISGT
STITIDEDKK RGDTLSETTP PKPVTNAFEI LGKAPSSPVK QKSGPQPPIH LSSQASIDSH
SLPLTFISQF LSPSLASALY LLMMEESKSW AAKRFYIAGK AAKSPHTTGF YRKEGGGYGG
GKYFYAGMEQ RSAKVYPTLL ARAAEIVEKA VNENLRKRPR YGPEWAGEWK ANVCGANHYD
GSRSSVGWHA DQLTYLGPYT TIASLSLGTS RAFRLRETPS DPAFIMNDKL PRTYEIILAH
NTLCLMNAGC QERYKHTVPP QKAIDLFRPG YDIAGDPIPK DAQQAFTSRI NITFRFYRED
FHPVPNAGPF GPREGTPTCR CGVPTVLRAD QKAKARSRLS SASSKPRPRV SSSMNIIEDD
MIFFWQCQSA TQTGVGKGCG FFKILDMKKE GRGPCIGDGV
//
