ID J9W2H8_CRYNH Unreviewed; 1864 AA.
AC J9W2H8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Rho guanyl-nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=CNAG_07903 {ECO:0000313|EMBL:AFR98335.2};
OS Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 /
OS CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=235443 {ECO:0000313|EMBL:AFR98335.2, ECO:0000313|Proteomes:UP000010091};
RN [1] {ECO:0000313|EMBL:AFR98335.2, ECO:0000313|Proteomes:UP000010091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H99 / ATCC 208821 / CBS 10515 / FGSC 9487
RC {ECO:0000313|Proteomes:UP000010091};
RX PubMed=24743168; DOI=10.1371/journal.pgen.1004261;
RA Janbon G., Ormerod K.L., Paulet D., Byrnes E.J.III., Yadav V.,
RA Chatterjee G., Mullapudi N., Hon C.C., Billmyre R.B., Brunel F., Bahn Y.S.,
RA Chen W., Chen Y., Chow E.W., Coppee J.Y., Floyd-Averette A., Gaillardin C.,
RA Gerik K.J., Goldberg J., Gonzalez-Hilarion S., Gujja S., Hamlin J.L.,
RA Hsueh Y.P., Ianiri G., Jones S., Kodira C.D., Kozubowski L., Lam W.,
RA Marra M., Mesner L.D., Mieczkowski P.A., Moyrand F., Nielsen K., Proux C.,
RA Rossignol T., Schein J.E., Sun S., Wollschlaeger C., Wood I.A., Zeng Q.,
RA Neuveglise C., Newlon C.S., Perfect J.R., Lodge J.K., Idnurm A.,
RA Stajich J.E., Kronstad J.W., Sanyal K., Heitman J., Fraser J.A.,
RA Cuomo C.A., Dietrich F.S.;
RT "Analysis of the genome and transcriptome of Cryptococcus neoformans var.
RT grubii reveals complex RNA expression and microevolution leading to
RT virulence attenuation.";
RL PLoS Genet. 10:E1004261-E1004261(2014).
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DR EMBL; CP003831; AFR98335.2; -; Genomic_DNA.
DR RefSeq; XP_012053003.1; XM_012197613.1.
DR GeneID; 23890713; -.
DR KEGG; cng:CNAG_07903; -.
DR VEuPathDB; FungiDB:CNAG_07903; -.
DR HOGENOM; CLU_001251_1_0_1; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000010091; Chromosome 12.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
FT DOMAIN 657..838
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 881..1076
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1114..1272
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1311..1622
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..1838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..462
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1824..1838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1864 AA; 208666 MW; 71DBF14009DBF5AD CRC64;
MSNSGGNLGD FRPHNGSAAS APAARRPLPP QPPRPALPPN PYPSYQSPAV PYTAPLADII
TPNSGSLGRR ALPTPPVSSN DHSPSRSRAL PTPPGRLPSG SYPDGPPPPP PPRPSDYFTY
ASREKTPLPL QPAAPRTESS LSPSPSSSRL DHSYEFTSSS RSSSQPKSAV DAIYTSNTSQ
SDHTNKSPNM THSNLDNEWL PILERFGDLS TNLNDSLKAP SSLHDGHGRD TPIQKSWPGP
GDMDSGGHDR LAAETFMTTT AYHPSPQYND SLESPGALKV NGALGVPSNG WPAYLQPEAR
TGRDRSASAV TMKAGDVHGG AITPRGDEKY DKDTLFGSAA KDEKPGEPQR QYSDTSYATG
NSVPLSTPDS LSSGGPGSPD PPHRQNSSTS SLYPRSITHN TGRASFDLSP SWAHQAQTPS
HWVERKLQIH QSHRHPSLAD SFEHEQGPSE WEEDEWEEEE DEEIDVDEGQ FFQPAFLSEM
ALQLRDKVER RRHIKAGIAW VGSFTGKDIV TTIHNLLPPH TREKLNDRRF ALLLAQSLQN
QLWFVEVDWD IKPLRDSSDD VFRFMGEMEG MASGADALTT ELPKGLMTMA TRCYSPSCTG
DKRCYSPRCP YKTSPDTFLP TKESITPLPT PVSIRHDDWK ENIDPLMLRD LSSRAITRQD
VIRQALSSEL AYEADLSIME DLFITHLRLA DPPIIPDPIH REEFIHEVFH NALELREASK
RLIEEFTIRQ REQPIIQFVG DLFLQAATEF RNIYPEYTGS LPQAEVALSK ELEENTEFRL
YTERVVREND RRRDIRHLIT RPSAQLQRYP ALLEGILNVT DSDDPDREFL SQALQSIQFI
SSLSQLKLFH ASKGRGPASK LEWFDLVTEE DRKTIPKKEQ KRQMLIWELI QGEIQYVADL
EVLGTVFAEG LRMAEPAVID RNRLDVFLDE AFHNWRSLYE IHSRFLQNLQ IRQLEQHPHI
GMISDLVFDA ALNWQEAYME YVPHYPIAKV KVQEEEASNS KFASFLKACL RDPMTNKQDI
DHFMSRPIFR LLRYPLLLDP IRNCLKETAG PDDPDYEQIP QVMEVIASLG KAIQKGVISN
ESKVELWAMQ RTLDGSKISP RTVADLDLAN PMRELIHRGT VYRQSEGSIG SGWTELNALL
FDNFLVLTKL ERPTKPSKSS RKKHSKERYA INRPPIPLEL LSLGSFSEAP RVRNTGRLFG
VGGASHYDIP SDKSMNAPKT PGSSKSADTS KLYPFSISFI GGQGQLGGSY TLWADSYKAR
QDWKEKFEHA KVLRAEINDA GKVFEMSPLS VDTFYMPPSY AMQKDKDSQY TGRVTCSCPF
ITQDQRRLVA VGCQDGVWIG IRGDSRSLRK VLHVKSVTSI AVLEEFSIFL VLSDKSLVAY
QLEALVPSAG QKPVKATTER ISMPKEEISS FTVGRLDGRT LLVIMRAETT QTVFKILEPV
LNKNTEDTTR QRRPFGFLGK TSEWFRPYKM FYLPAEVYGV HFLKHKMAIV CSKGFEIMDL
TDLKGGSIPI FDPAKIKEKP FLSDLERKCT QGRALGMFRS TETEFLLCYE TFGLYIHRYG
EPNRDCRPIE WQGRHDSVAF HPPYLLLISA PFIEIRHIDT GKLLQIYTGS DLRLTWDGSG
GQKNPPVLNP GKHGYGDETK IQEPQIHICQ RTTDHKQGRG QLAIGQVVYE LSPTLLLNNP
LLNPPNTLDP NYLPPVPLTS HANPAIRQAR PPSVRTTNSS DQFPHSNLYQ TSNPSQGYIP
FPNAQGYAAQ PPMLQRDSYG TQYSRDSSSY HDSNSVYNMT PIDPSPQSSA GAFPIQPQTQ
PAGYPSQGTN GGLGYAQYPA PQPPIVRGQS QGQDQGYGSY NDHVIRAWAQ NGGYGRNDAY
GGYE
//
