ID K0B331_9ARCH Unreviewed; 217 AA.
AC K0B331;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=NKOR_02625 {ECO:0000313|EMBL:AFS80423.1};
OS Candidatus Nitrosopumilus koreensis AR1.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC Nitrosopumilaceae; Nitrosopumilus.
OX NCBI_TaxID=1229908 {ECO:0000313|EMBL:AFS80423.1, ECO:0000313|Proteomes:UP000006101};
RN [1] {ECO:0000313|EMBL:AFS80423.1, ECO:0000313|Proteomes:UP000006101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR1 {ECO:0000313|EMBL:AFS80423.1,
RC ECO:0000313|Proteomes:UP000006101};
RX PubMed=23209206; DOI=10.1128/JB.01857-12;
RA Park S.J., Kim J.G., Jung M.Y., Kim S.J., Cha I.T., Kwon K., Lee J.H.,
RA Rhee S.K.;
RT "Draft Genome Sequence of an Ammonia-Oxidizing Archaeon, "Candidatus
RT Nitrosopumilus koreensis" AR1, from Marine Sediment.";
RL J. Bacteriol. 194:6940-6941(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
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DR EMBL; CP003842; AFS80423.1; -; Genomic_DNA.
DR RefSeq; WP_014962812.1; NC_018655.1.
DR AlphaFoldDB; K0B331; -.
DR STRING; 1229908.NKOR_02625; -.
DR GeneID; 13725970; -.
DR KEGG; nkr:NKOR_02625; -.
DR PATRIC; fig|1229908.8.peg.561; -.
DR HOGENOM; CLU_011276_8_2_2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000006101; Chromosome.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 217 AA; 24654 MW; B8F9E80B050B26C1 CRC64;
MIVDLNLHGK SIVVIGGGNE AQKRINSVIK QECDITVISD KVNSQINKLA KSKKIQLKKQ
KIQDTRFISE FKPDIIITTT NDKKLNQKII SAGKKRRIIT YSSDNPEESD FSNPAIIDFE
KIIQIAIFTG GQSPAMSKKI KQKSERVFRE IITKADISQI KIQKIARKVA KDHIPTPTER
KECLRSIMND NGIDQLIKDG QMKKAEKRAI TIVRNWE
//
