ID K0JGG2_BRAPL Unreviewed; 603 AA.
AC K0JGG2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Beta-glucuronidase {ECO:0000256|ARBA:ARBA00016205};
DE EC=3.2.1.31 {ECO:0000256|ARBA:ARBA00012761};
GN Name=uidA {ECO:0000313|EMBL:CCG57243.1};
GN ORFNames=WESB_1778 {ECO:0000313|EMBL:CCG57243.1};
OS Brachyspira pilosicoli WesB.
OC Bacteria; Spirochaetota; Spirochaetia; Brachyspirales; Brachyspiraceae;
OC Brachyspira.
OX NCBI_TaxID=1161918 {ECO:0000313|EMBL:CCG57243.1, ECO:0000313|Proteomes:UP000003759};
RN [1] {ECO:0000313|EMBL:CCG57243.1, ECO:0000313|Proteomes:UP000003759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WesB {ECO:0000313|EMBL:CCG57243.1};
RX PubMed=22947175; DOI=10.1186/1471-2164-13-454;
RA Mappley L.J., Black M.L., Abuoun M., Darby A.C., Woodward M.J.,
RA Parkhill J., Turner A.K., Bellgard M.I., La T., Phillips N.D.,
RA La Ragione R.M., Hampson D.J.;
RT "Comparative genomics of Brachyspira pilosicoli strains: genome
RT rearrangements, reductions and correlation of genetic compliment with
RT phenotypic diversity.";
RL BMC Genomics 13:454-454(2012).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
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DR EMBL; HE793032; CCG57243.1; -; Genomic_DNA.
DR RefSeq; WP_014933459.1; NC_018604.1.
DR AlphaFoldDB; K0JGG2; -.
DR SMR; K0JGG2; -.
DR KEGG; bpw:WESB_1778; -.
DR PATRIC; fig|1161918.5.peg.1290; -.
DR HOGENOM; CLU_006501_6_1_12; -.
DR OrthoDB; 9801077at2; -.
DR Proteomes; UP000003759; Chromosome.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154}.
FT DOMAIN 19..179
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 186..276
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 278..595
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 603 AA; 69087 MW; 6CF37772344FA97D CRC64;
MVNSMLYPRE SRTRRVVDIS GMWEFKIDIN NEGRNSGYAN GLKDTTFIPV PSSFNDLFTD
KNIREHAGDV WYETSFYLPL EWKDKDVNVR FGCATHEATV YINGKEVCTH VGGFMPFNAP
VNEAGIFGEK NKLVVVVNNE LSNTTIPCGH TETKPSGKKY IKPSFDFFNY AGLNRPVKIT
VTNKEYIHDI DILSDVNGSD GIVNYEVHTT GENKVYIKIN DEEGKEVASC EGKSGKIVIK
DAKLWNPKAA YLYKFIACIK NGDELIDEYY LDFGIRTVKV EGTKFLINGK PFYFTGFGKH
EDSEIAGRGY NPPVIKRDFE LIKWVGANSF RTSHYPYSEE IMQAADREGI VIIDEVAAVG
MFDVGSVLNP SASKTDYFSL DEVHSKTKEV HKKAVEELIK RDKNHPSVVM WSLFNEPDTS
KDEAVPYFED IFNFAKSQDK QNLPKTFAAI QASSPGKCKC MHLCDVITLN RYYGWYFLGG
YEIDMSEEKF REEMNLYSNM NKPVMFTEYG ADTYAGVHKL PSVMWSEEYQ CEYYEMNFKV
FDSYDFIVGE QLWNFADFQT TEGIFRVDGN KKGIFTRNRQ PKAVAHLIRS RWNKLPLDYK
SKK
//
