ID K0KMB5_WICCF Unreviewed; 958 AA.
AC K0KMB5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN Name=RPN2 {ECO:0000313|EMBL:CCH43332.1};
GN ORFNames=BN7_2880 {ECO:0000313|EMBL:CCH43332.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH43332.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH43332.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH43332.1}.
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DR EMBL; CAIF01000076; CCH43332.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KMB5; -.
DR STRING; 1206466.K0KMB5; -.
DR eggNOG; KOG2062; Eukaryota.
DR HOGENOM; CLU_002323_0_0_1; -.
DR InParanoid; K0KMB5; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 4.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5..315
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 763..932
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 816..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 105947 MW; FB896188FAD5E813 CRC64;
MATSTAAPYL ALLGEQDLNL KSYALKSIND IVDELWSEIA NNILEIEELY EDESFKDRKL
AALIASKVYY NLVDYDSSVK FALVADDAFD INEQSGYVET IISKAIDQYI RLSKEQYENE
NSQVEIPKQL QNIFERMLNK AIKENDLKSV IGLSLDSYRL DIVENIINEQ LKVDSEENVL
NLINYTLNIA TSIISNTSFR SKILNSLVSI ITNLKTPDFF IVSKIIVNLN DDSLAVHLFT
NLLKSEETNN RLIAYQVAFD LVNSSSQELL DKTIVKLSEL NSNESSPSPS ISKIIKILSG
IPSCDFDITF LHKNNNTDIQ ILNKARDSLE SRNSIFHSAI TFENAFMHAG TTDDSFFRSN
LEWLGKATNW SKFSATAALG VIHKGNLSQG RKILQPYLPG SSGSHYTKGG SLYALGLIFA
GHGRETIDYL RNHVVENGSS AGNDEVDVIL HGASLGTGVA GMGSGNEEIY EELKVVLYSD
SAISGEAAAL GMGLIMLGSG NESVQADMLS YAQETQHENI IRGLSTGIAL VNYGKEEQAD
EVISQLLEHQ NPLLRYGGAY TIALAYAGTG NNKAIKKLLH VAVSDSNDNV RRASVIALGF
VLIRDYQTVP RLVELLSESH NPHVRYGTAL ALGISCAGRG LQQAVDVLMP LTKDPVDFVR
QGALVALSMV LIQQNEKSNS KVTEVKELYA SIISSKSSDA LTKFGAALAQ GIIDAGGRNV
TIQVENGSTG TLNTKAIVGL AVFTQFWYWY PLTHFLSLAF TPTAIIGVRE DLKIPKFEIN
CHSKKSLFDY PPKVKEETTQ AYEKVETAVL STTAKAKARA KKSQKEKKED DMDVDEKPED
KTSKEESTKK DEEKDKEQQD TTITSEDNED NSVSKYSKTP FKLNNVTRVL PNQLKYIAFN
KDERFVPVRK YKGNGGVVVL IDKSPKEPIE SIKTVRQLNN KDAPLPEPFH LENTEEED
//
