ID K0KUV3_WICCF Unreviewed; 1047 AA.
AC K0KUV3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA mismatch repair protein MSH3 {ECO:0000256|ARBA:ARBA00019000};
DE AltName: Full=DNA mismatch repair protein msh3 {ECO:0000256|ARBA:ARBA00022151};
DE AltName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
GN ORFNames=BN7_6614 {ECO:0000313|EMBL:CCH47006.1};
OS Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM
OS 3599 / NBRC 0793 / NRRL Y-1031 F-60-10) (Yeast) (Pichia ciferrii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX NCBI_TaxID=1206466 {ECO:0000313|EMBL:CCH47006.1, ECO:0000313|Proteomes:UP000009328};
RN [1] {ECO:0000313|EMBL:CCH47006.1, ECO:0000313|Proteomes:UP000009328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
RC Y-1031 F-60-10 {ECO:0000313|Proteomes:UP000009328};
RX PubMed=23193139; DOI=10.1128/EC.00258-12;
RA Schneider J., Andrea H., Blom J., Jaenicke S., Ruckert C., Schorsch C.,
RA Szczepanowski R., Farwick M., Goesmann A., Puhler A., Schaffer S.,
RA Tauch A., Kohler T., Brinkrolf K.;
RT "Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-10.";
RL Eukaryot. Cell 11:1582-1583(2012).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH47006.1}.
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DR EMBL; CAIF01000297; CCH47006.1; -; Genomic_DNA.
DR AlphaFoldDB; K0KUV3; -.
DR STRING; 1206466.K0KUV3; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_2_1; -.
DR InParanoid; K0KUV3; -.
DR Proteomes; UP000009328; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009328}.
FT DOMAIN 892..908
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1047 AA; 121283 MW; 44A0648D3A694FC6 CRC64;
MKNSRTPTKS KGQPSISRFF KSSPKKQSTP PQQQNVQTIN IDDDGDDQIV EIINNDDINE
IKPSTVKTEV EIPNEINIER KKQFQYEKTT DIPIINPTTE QILLRESLKE KLSQKFSTNN
NPPNGVEESQ PQSDLEDDQT PQPPPKKKQK TSKQSKLTPL DQQVKDLKLL HLDKILAIQV
GYKYKFYCED AVKVHKILNI MLVPGKINII DESPTDKLYN KLAYCSIPEP RLHIHLQRLL
DRGLKIGIVD QIETSAIKSV ESKNSALFKR RLSNVFTKST YIEYDEVNQE KDKNINSLLS
IVEESVDQND NVLITLVSIQ PLTGEIIYDT FQDDFLRNEL ETRLLHMEPI EFIYFENDIS
ELTESCFQKF ISINSSNIRI NKIPILKKKF FESYLNDYVL DNPKLFEFIS EQSKEFQTCC
SLLIDYLKEF QLDSSFKIVT NYSNFIQKNH MILNSNSLTN LEIFINSTNN EQFGSLLWLM
DHTRTKFGYR LLRKWISNPL IDREQIEKRF DAVENIQSNF NHFLENLANL LKNSPDLEKI
LNRLHYGKVK RKELYIFLFK FEEISKLIIK FGKFEILNNL KSSYLKQLFT QLIEISESLK
ISNYVSMINS PNAMDDHNDD HILKYFNLNT LKINQDEIIT QDIEISNIKD EFQKELQNVR
DFLKRPSMDY VTSSREPYLV EIRAGLSRIV PKDWVKINGS KLVSRYRTPQ IIKLMKLLEY
HMELYLKACH SVFQRFVQDL DKNYTELNQF IKILAQYDCL LSITTTSSSL NYSRPKFVDE
QIIQIQNGRN PIIEQLNTYV PNDIDMNSSQ SRCFIITGPN MGGKSSYVKK VALLIIMAQC
GCFIPCESAT LGVFNSILTR MGSKDDLIKG ESTFFIEMSQ ILNVIQNCHG KSLIILDEVG
RGTGTIDGIS IASSILQYLM TETEKSLILF ITHFPSICKL SKKFSKIKNF HMGYIEEKKT
ENDWPKVTFL YNLVPGIAKN SYGLNVAKLA SINDEIIHNA FEISRKRQQQ VESAQNLANE
RKLVELFPKV LKGDKIEEIC DVIDDFD
//
