ID K0R1M3_THAOC Unreviewed; 235 AA.
AC K0R1M3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=THAOC_35517 {ECO:0000313|EMBL:EJK45845.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK45845.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK45845.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK45845.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK45845.1}.
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DR EMBL; AGNL01048202; EJK45845.1; -; Genomic_DNA.
DR AlphaFoldDB; K0R1M3; -.
DR EnsemblProtists; EJK45845; EJK45845; THAOC_35517.
DR eggNOG; ENOG502QPIQ; Eukaryota.
DR OMA; DQDIHIT; -.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR Gene3D; 3.40.50.11270; -; 1.
DR InterPro; IPR003451; LytB/IspH.
DR PANTHER; PTHR31619; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR31619:SF5; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE, CHLOROPLASTIC; 1.
DR Pfam; PF02401; LYTB; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000266841};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..235
FT /note="4-hydroxy-3-methylbut-2-enyl diphosphate reductase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003836537"
SQ SEQUENCE 235 AA; 26782 MW; 9669A0D15D66FC29 CRC64;
MFTSALPVVA LMAATQTEVD AFHAVPSARR STQLYSTVEK PKKKKKREKP NYIKNQREKI
AKGKSFYRGA GVFRDVKADV EQDMRDQFDS SLMNEMKDDP NYQLEKDGVM FYLAKDHGFC
WGVERSINLA YSAVESFPDQ DIHITNELIH NPMVNERLHN KNVNFIEKYE EDGTKDFSKI
KEGDVVMLPA FGATLDEMKE LDSKGVKIVD TTCPWVAKVW ATVHTHQVRG LTSGK
//
