ID K0SFR8_THAOC Unreviewed; 960 AA.
AC K0SFR8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN ORFNames=THAOC_15462 {ECO:0000313|EMBL:EJK63859.1};
OS Thalassiosira oceanica (Marine diatom).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=159749 {ECO:0000313|EMBL:EJK63859.1, ECO:0000313|Proteomes:UP000266841};
RN [1] {ECO:0000313|EMBL:EJK63859.1, ECO:0000313|Proteomes:UP000266841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1005 {ECO:0000313|EMBL:EJK63859.1,
RC ECO:0000313|Proteomes:UP000266841};
RX PubMed=22835381; DOI=10.1186/gb-2012-13-7-r66;
RA Lommer M., Specht M., Roy A.S., Kraemer L., Andreson R., Gutowska M.A.,
RA Wolf J., Bergner S.V., Schilhabel M.B., Klostermeier U.C., Beiko R.G.,
RA Rosenstiel P., Hippler M., Laroche J.;
RT "Genome and low-iron response of an oceanic diatom adapted to chronic iron
RT limitation.";
RL Genome Biol. 13:R66-R66(2012).
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJK63859.1}.
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DR EMBL; AGNL01017950; EJK63859.1; -; Genomic_DNA.
DR AlphaFoldDB; K0SFR8; -.
DR EnsemblProtists; EJK63859; EJK63859; THAOC_15462.
DR eggNOG; KOG1157; Eukaryota.
DR OMA; WLETHPH; -.
DR Proteomes; UP000266841; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000266841}.
FT DOMAIN 278..377
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 595..657
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 871..947
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 95..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 107749 MW; E682E9CFC236CF89 CRC64;
MLMSSVRRRL AYDNPRRWTY CRLGRKKSDL SSIRSRYLVG ARPRRQQRSE GEPAPTDFLL
FSSLTKQTVR HSPRIIRQHF IEEVQSNTLT LQSLPTANSI ESNTTGNDRT APSATSDDVF
AGKNNEVIVN GRKKEDGTQS KLGRKNGKTA KIDRRDNNGH GLTHGIGGKL NDGNDWGQNA
TKYSTAVNNV ICSGDEKDKD AMYDAQIRRL YASLVEKVSS YQPSAVLAIT TASMSDSNNG
TVGELQGVNN HTKPILQKAF EFSREAHKHQ CRKSGEPYII HPLGVAHIIA DMRLDLPSLL
TALLHDTVED TAVSLDDIDS LYGHEIASLV DGVTKVGKIP LASVEEVQSE NYRKLILSMS
RDIRVLLVKL ADRLHNMRTL EFMNPQKQKR IAKETIEIYA PLAHRLGIHW LKTELEDQCF
KYLKPGDYNK LHKLVTGSEG ERRQYEQQVV DLLSSQMEDA AAWNSHCFVC VVCFRIIVDD
VPSCYAALGV VHSHLKPVPG KIKDYVALPK PNGYQSLHTT VRYLKGKLEV QIRTRDMHSV
AESGIAAHFV YKEGGRMPKV GKNEQFAWLR QLVDDVRQQS DPLEFVSAVK EDLFQRECFV
FSPRGDLYAL ARGSSVLDFA FKVHSGLGSR CVGARVNGKM VSIKHNLNNG DTVEILTSNK
QKPKKEWLKY VRTSKAKSRI RSWLKRQQRD RSLASGKRML EREIEKYSAD DTGRKQYHRK
MEHVLTTFDL KDEEHLLVAL GYGQISLESV MIEVFGAAAV KTRGNSSQGD KREIDDEFVR
AKLTSDAAGA TERASGKHGI VVGKERNIML TFCKNCRPLH GEPIRGVVTK GKGVKVHRLG
CEVLLQADDK RIVDVRWDGG DLSGLQPRLA RIEALCEDSP GVLANLSRAI TSLGVNIGNV
SLRKLSNGRG LARMDVPVRS LEEFESLLAK YKRKEPWSKT DCFSIQSHTW SNTFILLYVP
//
