ID   K0UDC1_MYCVA            Unreviewed;       260 AA.
AC   K0UDC1;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Enoyl-CoA hydratase/isomerase {ECO:0000313|EMBL:EJZ05287.1};
GN   ORFNames=MVAC_25805 {ECO:0000313|EMBL:EJZ05287.1};
OS   Mycolicibacterium vaccae ATCC 25954.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ05287.1, ECO:0000313|Proteomes:UP000006072};
RN   [1] {ECO:0000313|EMBL:EJZ05287.1, ECO:0000313|Proteomes:UP000006072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ05287.1,
RC   ECO:0000313|Proteomes:UP000006072};
RX   PubMed=23105074; DOI=10.1128/JB.01462-12;
RA   Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA   Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT   "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL   J. Bacteriol. 194:6339-6340(2012).
CC   -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC       {ECO:0000256|ARBA:ARBA00002994}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023709};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023717};
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJZ05287.1}.
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DR   EMBL; ALQA01000084; EJZ05287.1; -; Genomic_DNA.
DR   RefSeq; WP_003929043.1; NZ_JH814684.1.
DR   AlphaFoldDB; K0UDC1; -.
DR   PATRIC; fig|1194972.3.peg.5138; -.
DR   eggNOG; COG1024; Bacteria.
DR   HOGENOM; CLU_009834_7_2_11; -.
DR   Proteomes; UP000006072; Unassembled WGS sequence.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   PANTHER; PTHR43459:SF1; EG:BACN32G11.4 PROTEIN; 1.
DR   PANTHER; PTHR43459; ENOYL-COA HYDRATASE; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:EJZ05287.1}.
SQ   SEQUENCE   260 AA;  27609 MW;  4C94A6DC1DDC0FEE CRC64;
     MDTPSPLIVD TDGAVATWTI NLPDVGNAIT STDFIAAFES AVDAVNRDLT VRAVILTGTG
     KIFSAGGNVK EMADRQGMFG LDAIAQRYAY VDGIQRIPRA LARLEVPVIA AVNGPAIGAG
     CDLATMCDLR VASERASFAE SFVQIGLVPG DGGTWFLQRA IGYERAAEMT LTGDRIDAAT
     ALEWGLVSCV VPHEQLLTAA GDLAARIAKN PPHALRMAKR LLQESRTGAL ESTLGMAAAM
     QPLAHHDAEH EARISRWRTT
//