ID K0UVU5_MYCVA Unreviewed; 359 AA.
AC K0UVU5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Polyprenyl synthetase {ECO:0000313|EMBL:EJZ09185.1};
GN ORFNames=MVAC_13171 {ECO:0000313|EMBL:EJZ09185.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ09185.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ09185.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ09185.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- PATHWAY: Isoprenoid biosynthesis. {ECO:0000256|ARBA:ARBA00005128}.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ09185.1}.
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DR EMBL; ALQA01000024; EJZ09185.1; -; Genomic_DNA.
DR RefSeq; WP_003933055.1; NZ_JH814698.1.
DR AlphaFoldDB; K0UVU5; -.
DR PATRIC; fig|1194972.3.peg.2633; -.
DR eggNOG; COG0142; Bacteria.
DR HOGENOM; CLU_014015_2_1_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001:SF88; (2E,6E)-FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 359 AA; 38377 MW; 3381DB171AA13097 CRC64;
MDTSAPSAAE LAAAVTEQLR EYLHERRRDA AYIGADYSVL TEAVEEFVLR GGKRLRPAFA
YWGWRAVAGT EPGPEVLRLF SALELLQACA LVHDDVIDAS ATRRGLPTVH RIFADRHREN
HWLGSSEQFG LSAAILLGDV ALVWADDIVA GADIDPDAHR RVQRVWSAIR TEVLGGQYLD
IVNEATGAET VEAALTVNIY KTASYTISRP LQLGAAAAAD CPEVLAAFHE LGTSLGVAFQ
LRDDVLGVFG DPAVTGKPSG DDLRSGKRTV LLAEAIQLAE QSDPVAAQLL RGSVGTELSE
VQVKELCLAI ESVGALAAVE RRIGTLTRRA LEILNTAPID AKAKAGLSEL ARLAANRSA
//
