ID K0UXD2_MYCVA Unreviewed; 382 AA.
AC K0UXD2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Inosine 5-monophosphate dehydrogenase {ECO:0000313|EMBL:EJZ11792.1};
DE EC=1.1.1.205 {ECO:0000313|EMBL:EJZ11792.1};
GN ORFNames=MVAC_04437 {ECO:0000313|EMBL:EJZ11792.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ11792.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ11792.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ11792.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC {ECO:0000256|ARBA:ARBA00005502}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ11792.1}.
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DR EMBL; ALQA01000006; EJZ11792.1; -; Genomic_DNA.
DR RefSeq; WP_003929265.1; NZ_JH814686.1.
DR AlphaFoldDB; K0UXD2; -.
DR PATRIC; fig|1194972.3.peg.896; -.
DR eggNOG; COG0516; Bacteria.
DR HOGENOM; CLU_064068_0_0_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR CDD; cd00381; IMPDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR005990; IMP_DH.
DR InterPro; IPR005992; IMP_DH-rel2.
DR InterPro; IPR001093; IMP_DH_GMPRt.
DR NCBIfam; TIGR01304; IMP_DH_rel_2; 1.
DR PANTHER; PTHR11911:SF85; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR Pfam; PF00478; IMPDH; 1.
DR SMART; SM01240; IMPDH; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:EJZ11792.1}.
FT DOMAIN 19..307
FT /note="IMP dehydrogenase/GMP reductase"
FT /evidence="ECO:0000259|Pfam:PF00478"
SQ SEQUENCE 382 AA; 39748 MW; C470070E14144693 CRC64;
MREMVEIGMG RTARRTYELD DINIVPSRRT RSSKDVSTAW QLDAYRFEIP VVAHPTDALV
SVEFAIEMGR SGGLGVLNGE GLIGRHSDVA DKIAQVIEVA EKDPDPAAAT RLLQQLHSAP
IDLDLLGAAV ARIREAGVTT AVRVSPQNAQ ALTPTLVAAG IDLLVIQGTI ISAERVAKGS
DETGEPLNLK TFISELDVPV VAGGVLDHRT ALHLMRTGAA GVIVGYGSTA GVTTSDEVLG
ISVPMATAIA DAAAARREYL DETGGRYVHV LADGDIHTSG DLAKAIACGA DAVVLGTPLA
VSAEALGGGW FWPSAAAHPS LPRGALLQVA DEDRPSLEQV LNGPSDDPFG SLNLVGGLAR
SMAKAGYCDL KEFQKVGLTV GS
//
