ID K0V2S6_MYCVA Unreviewed; 632 AA.
AC K0V2S6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:EJZ09178.1};
GN ORFNames=MVAC_13136 {ECO:0000313|EMBL:EJZ09178.1};
OS Mycolicibacterium vaccae ATCC 25954.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1194972 {ECO:0000313|EMBL:EJZ09178.1, ECO:0000313|Proteomes:UP000006072};
RN [1] {ECO:0000313|EMBL:EJZ09178.1, ECO:0000313|Proteomes:UP000006072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25954 {ECO:0000313|EMBL:EJZ09178.1,
RC ECO:0000313|Proteomes:UP000006072};
RX PubMed=23105074; DOI=10.1128/JB.01462-12;
RA Ho Y.S., Adroub S.A., Abadi M., Al Alwan B., Alkhateeb R., Gao G.,
RA Ragab A., Ali S., van Soolingen D., Bitter W., Pain A., Abdallah A.M.;
RT "Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954.";
RL J. Bacteriol. 194:6339-6340(2012).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ09178.1}.
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DR EMBL; ALQA01000024; EJZ09178.1; -; Genomic_DNA.
DR RefSeq; WP_003933048.1; NZ_JH814698.1.
DR AlphaFoldDB; K0V2S6; -.
DR PATRIC; fig|1194972.3.peg.2626; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_5_11; -.
DR Proteomes; UP000006072; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:EJZ09178.1};
KW Cell division {ECO:0000313|EMBL:EJZ09178.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 80..248
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 292..607
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 67294 MW; 52F87C22009C1D9F CRC64;
MSRAKAPNQE RSARSRRTRQ AATQTGLRSA SFVFRHRTGN AVIFLLLVVA AAQLFTLQVP
RAEGLRAEAA SQLKVTDIDP ALRGAIVDRN GDKLAFTTEA RALTFQPVRV RKQLEEAFAK
NAELNTEDAP DPDARLRDIA AEVSSRLAGR PDTATVLKKL RSNETFVYLA RAVDPAIADA
ITTKFPEVGA ERQDLRQYPG GVLAANIIGG IDWDGHGLLG LEDSLDSVLA GTDGSVTYDR
GSDGVVIPGS YRNRHDAVNG STVTLTIDDD IQFHVQQQVQ MAKDASGAKN ASAVVLDAKT
GEVLAMANDN TFNPAQDLSR QKGRQLGNLS VSSPFEPGSV NKMITAAAVI ENGLTTPDEV
LQVPGSINMG GVTVGDAWDH GVMPYTTTGV FGKSSNVGTL MLAQRLGPER FAEMLKLFGL
GQRTGVGLPG ESAGLVPPID QWSGSTFSNL PIGQGLSMTL LQMTGIYQAI ANDGVRIPPR
IIKDIVAPDG ARADEPRPQG VRVVSPETAR TVRDMFRSVV QRDPRGIQQG TGPQAAVEGY
QIAGKTGTAQ QINPACGCYY DDVYWITFAG MAPADDPRYV IGVMLDAPHR AADGTPGSSA
APLFHDIASW LLQRENVPLS ADPGAPLTLQ AD
//
