ID K0XHU8_9FIRM Unreviewed; 164 AA.
AC K0XHU8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=HMPREF1135_00982 {ECO:0000313|EMBL:EJZ70146.1};
OS Lachnoanaerobaculum sp. OBRC5-5.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Lachnoanaerobaculum.
OX NCBI_TaxID=936595 {ECO:0000313|EMBL:EJZ70146.1, ECO:0000313|Proteomes:UP000006070};
RN [1] {ECO:0000313|EMBL:EJZ70146.1, ECO:0000313|Proteomes:UP000006070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OBRC5-5 {ECO:0000313|EMBL:EJZ70146.1,
RC ECO:0000313|Proteomes:UP000006070};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sizova M., Hazen A.,
RA Epstein S., Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridiales bacterium OBRC5-5.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJZ70146.1}.
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DR EMBL; ALOA01000006; EJZ70146.1; -; Genomic_DNA.
DR RefSeq; WP_007592680.1; NZ_JH815185.1.
DR AlphaFoldDB; K0XHU8; -.
DR STRING; 936595.HMPREF1135_00982; -.
DR PATRIC; fig|1125778.3.peg.989; -.
DR HOGENOM; CLU_043966_5_2_9; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000006070; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..163
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 164 AA; 18813 MW; 64DCF57AC5607497 CRC64;
MNIIVSVDKK WGIGNKGKLL VSIPKDMKLF REETVGKVII MGHNTLLSLP GSQPLAGREN
IVLSKDKNLK IKGATVVNSV ESCLEYLKEN NINNENVFVI GGESVYRNFL PYCNVAHVTY
IDYEYAADRH FLNLDADKEW SLLLETEEET YFDIPYTFRM YKRV
//