ID K0ZHU3_9STRE Unreviewed; 789 AA.
AC K0ZHU3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=GMD6S_03695 {ECO:0000313|EMBL:EKA06645.1};
OS Streptococcus sp. GMD6S.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1169675 {ECO:0000313|EMBL:EKA06645.1, ECO:0000313|Proteomes:UP000004468};
RN [1] {ECO:0000313|EMBL:EKA06645.1, ECO:0000313|Proteomes:UP000004468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMD6S {ECO:0000313|EMBL:EKA06645.1,
RC ECO:0000313|Proteomes:UP000004468};
RX PubMed=23493677; DOI=10.1101/gr.142208.112;
RA Fitzsimons M.S., Novotny M., Lo C.C., Dichosa A.E., Yee-Greenbaum J.L.,
RA Snook J.P., Gu W., Chertkov O., Davenport K.W., McMurry K., Reitenga K.G.,
RA Daughton A.R., He J., Johnson S.L., Gleasner C.D., Wills P.L.,
RA Parson-Quintana B., Chain P.S., Detter J.C., Lasken R.S., Han C.S.;
RT "Nearly finished genomes produced using gel microdroplet culturing reveal
RT substantial intraspecies genomic diversity within the human microbiome.";
RL Genome Res. 23:878-888(2013).
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKA06645.1}.
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DR EMBL; AJRH01000013; EKA06645.1; -; Genomic_DNA.
DR RefSeq; WP_000454451.1; NZ_AJRH01000013.1.
DR AlphaFoldDB; K0ZHU3; -.
DR PATRIC; fig|1169675.3.peg.723; -.
DR Proteomes; UP000004468; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:EKA06645.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}.
FT DOMAIN 148..237
FT /note="RecD helicase-like helix-hairpin-helix"
FT /evidence="ECO:0000259|Pfam:PF14490"
FT DOMAIN 574..644
FT /note="RecD-like DNA helicase SH3"
FT /evidence="ECO:0000259|Pfam:PF18335"
FT DOMAIN 661..709
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT BINDING 356..360
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 789 AA; 88405 MW; 6612E6557E2C3238 CRC64;
MEVYFSGTIE RIIFENPSNF YRILLLDIED TDAEDFDDFE IIVTGTMADV IEGEDYTFWG
QIIQHSKYGE QLQISRYERA KPTKNGLVKY FSSSHFKGIG LKTAQKIVDS YGENTIDEIL
EHPEKLESIA GLSAKNREAF VSTLRLNYGT EMVLAKLANY GIPNKLAFQI QNFYKEETLD
IVENYPYQLV EDIKGLGFTI ADQLAAELGI ESQAPERFRA GLVHSLFQGC MDTGNTYMEA
RDLLEQTLTL LESSRPVELD PSQVAQELSH LIEEDKVQQI DTKIFDNSLF FAEEGIRSHL
VRILEKGKQK SHDLETIQKH IASVEKELGI QYDSIQKQAI CDAIQNKVFI LTGGPGTGKT
TVINGIIAIY ALLEGLDLRK KSNLPILLAA PTGRAARRMN ELTGLPSATI HRHLGMTGDD
DTSHLEDYLD ADFIIVDEFS MVDTWLANQL FSNISSNSKI LIVGDSDQLP SVSPGQVLAD
LLQISLIPQT RLERIYRQSE ESTIVTLASQ IRQGILPADF PQKKADRSYF EIASGHIPAT
IEKILGAALR SGIPARDIQV LAPMYRGTAG IDAINQLMQD LLNPQQKGQV SFEATQCHYR
TGDKVIHLVN DAEVNVFNGD LGYITDLIPG KYTESKQDEI VIDFDGNEVS YPRNEWYKIR
LAYAMSIHKS QGSEFPVVIL PITSASKRML ERNLIYTAIT RAKSKLILLG ELQAFDYAIK
HIGTARKTYL IERFSDLIET NIEESKQAFS ETATASDSEQ SYILTEENWS SIPAMIGITD
ADLKEIFGK
//
