ID K1C15_HUMAN Reviewed; 456 AA.
AC P19012; B3KQY1; B3KRA2; E0CX14; Q53XV8; Q9BUG4;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 24-JAN-2024, entry version 202.
DE RecName: Full=Keratin, type I cytoskeletal 15;
DE AltName: Full=Cytokeratin-15;
DE Short=CK-15;
DE AltName: Full=Keratin-15;
DE Short=K15;
GN Name=KRT15; Synonyms=KRTB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-147 AND GLY-421.
RX PubMed=2468493;
RA Bader B.L., Jahn L., Franke W.W.;
RT "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth
RT muscle cells of human umbilical cord and in cultured cells derived
RT therefrom, with an analysis of the chromosomal locus containing the
RT cytokeratin 19 gene.";
RL Eur. J. Cell Biol. 47:300-319(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP ALA-147 AND GLY-421.
RX PubMed=2452170; DOI=10.1083/jcb.106.4.1249;
RA Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T.,
RA Franke W.W.;
RT "Molecular characterization and expression of the stratification-related
RT cytokeratins 4 and 15.";
RL J. Cell Biol. 106:1249-1261(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10623642; DOI=10.1006/bbrc.1999.1966;
RA Whittock N.V., Eady R.A.J., McGrath J.A.;
RT "Genomic organization and amplification of the human keratin 15 and 19
RT genes.";
RL Biochem. Biophys. Res. Commun. 267:462-465(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-421.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ARG-416 AND GLY-421.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-421.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=10084315; DOI=10.1046/j.1523-1747.1999.00535.x;
RA Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S., Lalli A.,
RA Machesney M., Leigh I.M.;
RT "Keratin 15 expression in stratified epithelia: downregulation in activated
RT keratinocytes.";
RL J. Invest. Dermatol. 112:362-369(1999).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION IN A COMPLEX WITH KRT14, AND INTERACTION WITH KRT14 AND
RP PLEC.
RX PubMed=24940650; DOI=10.1038/jid.2014.255;
RA Bouameur J.E., Favre B., Fontao L., Lingasamy P., Begre N., Borradori L.;
RT "Interaction of plectin with keratins 5 and 14: dependence on several
RT plectin domains and keratin quaternary structure.";
RL J. Invest. Dermatol. 134:2776-2783(2014).
RN [11]
RP INTERACTION WITH NOD2.
RX PubMed=27812135; DOI=10.1371/journal.pone.0165420;
RA Thiebaut R., Esmiol S., Lecine P., Mahfouz B., Hermant A., Nicoletti C.,
RA Parnis S., Perroy J., Borg J.P., Pascoe L., Hugot J.P., Ollendorff V.;
RT "Characterization and Genetic Analyses of New Genes Coding for NOD2
RT Interacting Proteins.";
RL PLoS ONE 11:E0165420-E0165420(2016).
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins (By
CC similarity). Forms a heterodimer with KRT14 (PubMed:24940650).
CC Interacts with PLEC isoform 1C, when in a heterodimer with KRT14
CC (PubMed:24940650). Interacts with NOD2 (PubMed:27812135).
CC {ECO:0000250|UniProtKB:Q61414, ECO:0000269|PubMed:24940650,
CC ECO:0000269|PubMed:27812135}.
CC -!- INTERACTION:
CC P19012; Q9NYB9: ABI2; NbExp=6; IntAct=EBI-739566, EBI-743598;
CC P19012; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-739566, EBI-11096309;
CC P19012; A2BDD9: AMOT; NbExp=3; IntAct=EBI-739566, EBI-17286414;
CC P19012; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-739566, EBI-3891843;
CC P19012; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-739566, EBI-10187270;
CC P19012; Q96IX9: ANKRD36BP1; NbExp=4; IntAct=EBI-739566, EBI-744859;
CC P19012; P53365: ARFIP2; NbExp=6; IntAct=EBI-739566, EBI-638194;
CC P19012; P48047: ATP5PO; NbExp=3; IntAct=EBI-739566, EBI-355815;
CC P19012; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739566, EBI-745073;
CC P19012; Q8TAB5: C1orf216; NbExp=4; IntAct=EBI-739566, EBI-747505;
CC P19012; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-739566, EBI-739879;
CC P19012; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-739566, EBI-11530605;
CC P19012; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-739566, EBI-749261;
CC P19012; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-739566, EBI-10175300;
CC P19012; Q9NPC3: CCNB1IP1; NbExp=4; IntAct=EBI-739566, EBI-745269;
CC P19012; P24863: CCNC; NbExp=3; IntAct=EBI-739566, EBI-395261;
CC P19012; Q07002: CDK18; NbExp=3; IntAct=EBI-739566, EBI-746238;
CC P19012; Q86XR8: CEP57; NbExp=3; IntAct=EBI-739566, EBI-308614;
CC P19012; P10606: COX5B; NbExp=3; IntAct=EBI-739566, EBI-1053725;
CC P19012; Q02930-3: CREB5; NbExp=3; IntAct=EBI-739566, EBI-10192698;
CC P19012; Q8WWE8: CYTH4; NbExp=3; IntAct=EBI-739566, EBI-10277443;
CC P19012; P17661: DES; NbExp=3; IntAct=EBI-739566, EBI-1055572;
CC P19012; Q05D60: DEUP1; NbExp=6; IntAct=EBI-739566, EBI-748597;
CC P19012; O60941-5: DTNB; NbExp=3; IntAct=EBI-739566, EBI-11984733;
CC P19012; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-739566, EBI-743105;
CC P19012; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739566, EBI-744099;
CC P19012; Q9H2F5: EPC1; NbExp=3; IntAct=EBI-739566, EBI-769270;
CC P19012; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-739566, EBI-1752811;
CC P19012; O95995: GAS8; NbExp=3; IntAct=EBI-739566, EBI-1052570;
CC P19012; P14136: GFAP; NbExp=9; IntAct=EBI-739566, EBI-744302;
CC P19012; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-739566, EBI-748515;
CC P19012; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-739566, EBI-11956675;
CC P19012; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739566, EBI-2514791;
CC P19012; O14964: HGS; NbExp=6; IntAct=EBI-739566, EBI-740220;
CC P19012; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-739566, EBI-713401;
CC P19012; Q70UQ0: IKBIP; NbExp=3; IntAct=EBI-739566, EBI-2557212;
CC P19012; Q7Z3B3: KANSL1; NbExp=5; IntAct=EBI-739566, EBI-740244;
CC P19012; O60341: KDM1A; NbExp=3; IntAct=EBI-739566, EBI-710124;
CC P19012; Q5T5P2-6: KIAA1217; NbExp=3; IntAct=EBI-739566, EBI-10188326;
CC P19012; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-739566, EBI-2125614;
CC P19012; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-739566, EBI-14069005;
CC P19012; Q6P597: KLC3; NbExp=3; IntAct=EBI-739566, EBI-1643885;
CC P19012; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-739566, EBI-949319;
CC P19012; P04264: KRT1; NbExp=7; IntAct=EBI-739566, EBI-298429;
CC P19012; P35908: KRT2; NbExp=7; IntAct=EBI-739566, EBI-1247312;
CC P19012; P35900: KRT20; NbExp=5; IntAct=EBI-739566, EBI-742094;
CC P19012; P19013: KRT4; NbExp=6; IntAct=EBI-739566, EBI-2371606;
CC P19012; P13647: KRT5; NbExp=6; IntAct=EBI-739566, EBI-702187;
CC P19012; P02538: KRT6A; NbExp=15; IntAct=EBI-739566, EBI-702198;
CC P19012; P04259: KRT6B; NbExp=7; IntAct=EBI-739566, EBI-740907;
CC P19012; P48668: KRT6C; NbExp=3; IntAct=EBI-739566, EBI-2564105;
CC P19012; Q3SY84: KRT71; NbExp=6; IntAct=EBI-739566, EBI-2952676;
CC P19012; Q14CN4: KRT72; NbExp=3; IntAct=EBI-739566, EBI-1221280;
CC P19012; Q86Y46: KRT73; NbExp=3; IntAct=EBI-739566, EBI-2830994;
CC P19012; Q86Y46-2: KRT73; NbExp=3; IntAct=EBI-739566, EBI-12039441;
CC P19012; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-739566, EBI-968660;
CC P19012; O95678: KRT75; NbExp=3; IntAct=EBI-739566, EBI-2949715;
CC P19012; Q0IIN1: KRT77; NbExp=3; IntAct=EBI-739566, EBI-2511085;
CC P19012; Q7Z794: KRT77; NbExp=3; IntAct=EBI-739566, EBI-3045529;
CC P19012; Q8N1N4: KRT78; NbExp=3; IntAct=EBI-739566, EBI-1056564;
CC P19012; Q5XKE5: KRT79; NbExp=7; IntAct=EBI-739566, EBI-2514135;
CC P19012; P05787: KRT8; NbExp=6; IntAct=EBI-739566, EBI-297852;
CC P19012; Q6KB66: KRT80; NbExp=3; IntAct=EBI-739566, EBI-3046635;
CC P19012; Q6KB66-2: KRT80; NbExp=3; IntAct=EBI-739566, EBI-11999246;
CC P19012; Q14533: KRT81; NbExp=4; IntAct=EBI-739566, EBI-739648;
CC P19012; Q9NSB4: KRT82; NbExp=3; IntAct=EBI-739566, EBI-1045341;
CC P19012; P78385: KRT83; NbExp=3; IntAct=EBI-739566, EBI-10221390;
CC P19012; P78386: KRT85; NbExp=3; IntAct=EBI-739566, EBI-1049371;
CC P19012; O43790: KRT86; NbExp=7; IntAct=EBI-739566, EBI-9996498;
CC P19012; P25791: LMO2; NbExp=3; IntAct=EBI-739566, EBI-739696;
CC P19012; P61968: LMO4; NbExp=6; IntAct=EBI-739566, EBI-2798728;
CC P19012; Q8TBB1: LNX1; NbExp=5; IntAct=EBI-739566, EBI-739832;
CC P19012; O95983: MBD3; NbExp=3; IntAct=EBI-739566, EBI-1783068;
CC P19012; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739566, EBI-14086479;
CC P19012; Q6PF18: MORN3; NbExp=3; IntAct=EBI-739566, EBI-9675802;
CC P19012; P00540: MOS; NbExp=6; IntAct=EBI-739566, EBI-1757866;
CC P19012; I6L9F6: NEFL; NbExp=3; IntAct=EBI-739566, EBI-10178578;
CC P19012; P07196: NEFL; NbExp=3; IntAct=EBI-739566, EBI-475646;
CC P19012; Q9BVI4: NOC4L; NbExp=4; IntAct=EBI-739566, EBI-395927;
CC P19012; Q7Z3B4: NUP54; NbExp=4; IntAct=EBI-739566, EBI-741048;
CC P19012; O43482: OIP5; NbExp=4; IntAct=EBI-739566, EBI-536879;
CC P19012; O00459: PIK3R2; NbExp=3; IntAct=EBI-739566, EBI-346930;
CC P19012; Q16512: PKN1; NbExp=3; IntAct=EBI-739566, EBI-602382;
CC P19012; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-739566, EBI-2557469;
CC P19012; Q8WWY3: PRPF31; NbExp=9; IntAct=EBI-739566, EBI-1567797;
CC P19012; P25786: PSMA1; NbExp=4; IntAct=EBI-739566, EBI-359352;
CC P19012; P20618: PSMB1; NbExp=7; IntAct=EBI-739566, EBI-372273;
CC P19012; O75771: RAD51D; NbExp=7; IntAct=EBI-739566, EBI-1055693;
CC P19012; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-739566, EBI-744023;
CC P19012; Q9P2K3: RCOR3; NbExp=5; IntAct=EBI-739566, EBI-743428;
CC P19012; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-739566, EBI-1504830;
CC P19012; Q8N443: RIBC1; NbExp=3; IntAct=EBI-739566, EBI-10265323;
CC P19012; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-739566, EBI-16428950;
CC P19012; Q9BUL9: RPP25; NbExp=3; IntAct=EBI-739566, EBI-366570;
CC P19012; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-739566, EBI-748350;
CC P19012; Q96ES7: SGF29; NbExp=7; IntAct=EBI-739566, EBI-743117;
CC P19012; Q96GM5: SMARCD1; NbExp=4; IntAct=EBI-739566, EBI-358489;
CC P19012; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-739566, EBI-455078;
CC P19012; O95295: SNAPIN; NbExp=3; IntAct=EBI-739566, EBI-296723;
CC P19012; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-739566, EBI-742688;
CC P19012; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-739566, EBI-2212028;
CC P19012; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-739566, EBI-12018146;
CC P19012; Q9BT92: TCHP; NbExp=5; IntAct=EBI-739566, EBI-740781;
CC P19012; O60220: TIMM8A; NbExp=3; IntAct=EBI-739566, EBI-1049822;
CC P19012; Q08117: TLE5; NbExp=3; IntAct=EBI-739566, EBI-717810;
CC P19012; Q0P5Q0: TMSB4X; NbExp=3; IntAct=EBI-739566, EBI-10226570;
CC P19012; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-739566, EBI-5235829;
CC P19012; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-739566, EBI-11059915;
CC P19012; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-739566, EBI-9090990;
CC P19012; P40222: TXLNA; NbExp=6; IntAct=EBI-739566, EBI-359793;
CC P19012; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-739566, EBI-6116822;
CC P19012; O75604: USP2; NbExp=5; IntAct=EBI-739566, EBI-743272;
CC P19012; Q9BTA9: WAC; NbExp=4; IntAct=EBI-739566, EBI-749118;
CC P19012; Q9BTA9-2: WAC; NbExp=3; IntAct=EBI-739566, EBI-10298216;
CC P19012; Q53FD0: ZC2HC1C; NbExp=4; IntAct=EBI-739566, EBI-740767;
CC P19012; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-739566, EBI-14104088;
CC P19012; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-739566, EBI-8656416;
CC P19012; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-739566, EBI-3439227;
CC P19012; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-739566, EBI-10183064;
CC P19012; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-739566, EBI-740727;
CC P19012; Q9H609: ZNF576; NbExp=3; IntAct=EBI-739566, EBI-3921014;
CC P19012; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739566, EBI-16429014;
CC P19012; P14079: tax; Xeno; NbExp=3; IntAct=EBI-739566, EBI-9675698;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P19012-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P19012-2; Sequence=VSP_056507, VSP_056508, VSP_056509;
CC -!- TISSUE SPECIFICITY: Expressed in a discontinuous manner in the basal
CC cell layer of adult skin epidermis, but continuously in the basal layer
CC of fetal skin epidermis and nail. Also expressed in the outer root
CC sheath above the hair bulb in hair follicle (at protein level).
CC Expressed homogeneously in all cell layers of the esophagus and
CC exocervix, but detected in the basal cell layer only of oral mucosa,
CC skin and in the basal plus the next two layers of the suprabasal
CC epithelium of the palate. {ECO:0000269|PubMed:10084315,
CC ECO:0000269|PubMed:2452170}.
CC -!- MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar
CC keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR EMBL; X07696; CAA30535.1; -; mRNA.
DR EMBL; AF202320; AAF27047.1; -; Genomic_DNA.
DR EMBL; BT007261; AAP35925.1; -; mRNA.
DR EMBL; AK090604; BAG52193.1; -; mRNA.
DR EMBL; AK091239; BAG52314.1; -; mRNA.
DR EMBL; AC019349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002641; AAH02641.1; -; mRNA.
DR CCDS; CCDS11398.1; -. [P19012-1]
DR PIR; S01069; KRHU5.
DR RefSeq; NP_002266.2; NM_002275.3. [P19012-1]
DR AlphaFoldDB; P19012; -.
DR SMR; P19012; -.
DR BioGRID; 110064; 178.
DR IntAct; P19012; 157.
DR MINT; P19012; -.
DR STRING; 9606.ENSP00000377546; -.
DR iPTMnet; P19012; -.
DR PhosphoSitePlus; P19012; -.
DR SwissPalm; P19012; -.
DR BioMuta; KRT15; -.
DR DMDM; 311033438; -.
DR jPOST; P19012; -.
DR MassIVE; P19012; -.
DR MaxQB; P19012; -.
DR PaxDb; 9606-ENSP00000254043; -.
DR PeptideAtlas; P19012; -.
DR PRIDE; P19012; -.
DR ProteomicsDB; 3590; -.
DR ProteomicsDB; 53620; -. [P19012-1]
DR Antibodypedia; 3601; 995 antibodies from 42 providers.
DR DNASU; 3866; -.
DR Ensembl; ENST00000254043.8; ENSP00000254043.3; ENSG00000171346.16. [P19012-1]
DR Ensembl; ENST00000393976.6; ENSP00000377546.1; ENSG00000171346.16. [P19012-1]
DR GeneID; 3866; -.
DR KEGG; hsa:3866; -.
DR MANE-Select; ENST00000254043.8; ENSP00000254043.3; NM_002275.4; NP_002266.3.
DR UCSC; uc002hwy.4; human. [P19012-1]
DR AGR; HGNC:6421; -.
DR CTD; 3866; -.
DR DisGeNET; 3866; -.
DR GeneCards; KRT15; -.
DR HGNC; HGNC:6421; KRT15.
DR HPA; ENSG00000171346; Group enriched (breast, esophagus, skin, vagina).
DR MIM; 148030; gene.
DR neXtProt; NX_P19012; -.
DR OpenTargets; ENSG00000171346; -.
DR PharmGKB; PA30208; -.
DR VEuPathDB; HostDB:ENSG00000171346; -.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000154403; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; P19012; -.
DR OMA; ADLRNDM; -.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; P19012; -.
DR TreeFam; TF332742; -.
DR PathwayCommons; P19012; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; P19012; -.
DR SIGNOR; P19012; -.
DR BioGRID-ORCS; 3866; 12 hits in 1160 CRISPR screens.
DR ChiTaRS; KRT15; human.
DR GeneWiki; Keratin_15; -.
DR GenomeRNAi; 3866; -.
DR Pharos; P19012; Tbio.
DR PRO; PR:P19012; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P19012; Protein.
DR Bgee; ENSG00000171346; Expressed in lower esophagus mucosa and 128 other cell types or tissues.
DR ExpressionAtlas; P19012; baseline and differential.
DR Genevisible; P19012; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
DR GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF164; KERATIN, TYPE I CYTOSKELETAL 15; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Intermediate filament; Isopeptide bond;
KW Keratin; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..456
FT /note="Keratin, type I cytoskeletal 15"
FT /id="PRO_0000063657"
FT DOMAIN 105..417
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..104
FT /note="Head"
FT REGION 105..140
FT /note="Coil 1A"
FT REGION 141..159
FT /note="Linker 1"
FT REGION 160..251
FT /note="Coil 1B"
FT REGION 252..271
FT /note="Linker 12"
FT REGION 272..413
FT /note="Coil 2"
FT REGION 414..456
FT /note="Tail"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q04695"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q61414"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q04695"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q04695"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q04695"
FT MOD_RES 301
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFV3"
FT MOD_RES 323
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6IFV3"
FT CROSSLNK 300
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q04695"
FT VAR_SEQ 3..29
FT /note="TTFLQTSSSTFGGGSTRGGSLLAGGGG -> GTRSRPQPAQNATTANTSRPL
FT KSSGTR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056507"
FT VAR_SEQ 30..194
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056508"
FT VAR_SEQ 417..456
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056509"
FT VARIANT 147
FT /note="T -> A (in dbSNP:rs1050784)"
FT /evidence="ECO:0000269|PubMed:2452170,
FT ECO:0000269|PubMed:2468493"
FT /id="VAR_047429"
FT VARIANT 416
FT /note="K -> R (in dbSNP:rs2305556)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_047430"
FT VARIANT 421
FT /note="A -> G (in dbSNP:rs897420)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:2452170,
FT ECO:0000269|PubMed:2468493, ECO:0000269|Ref.4"
FT /id="VAR_047431"
SQ SEQUENCE 456 AA; 49212 MW; 812C1343905EBE41 CRC64;
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI
//
