ID   K1JR48_9BURK            Unreviewed;       214 AA.
AC   K1JR48;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE            EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE   AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN   ORFNames=HMPREF9465_02179 {ECO:0000313|EMBL:EKB30172.1};
OS   Sutterella wadsworthensis 2_1_59BFAA.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sutterellaceae; Sutterella.
OX   NCBI_TaxID=742823 {ECO:0000313|EMBL:EKB30172.1, ECO:0000313|Proteomes:UP000005835};
RN   [1] {ECO:0000313|EMBL:EKB30172.1, ECO:0000313|Proteomes:UP000005835}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2_1_59BFAA {ECO:0000313|EMBL:EKB30172.1,
RC   ECO:0000313|Proteomes:UP000005835};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Allen-Vercoe E., Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA   Imamovic A., Larimer J., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Sutterella wadsworthensis 2_1_59BFAA.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC       from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKB30172.1}.
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DR   EMBL; ADMG01000051; EKB30172.1; -; Genomic_DNA.
DR   RefSeq; WP_005437023.1; NZ_JH815521.1.
DR   AlphaFoldDB; K1JR48; -.
DR   STRING; 742823.HMPREF9465_02179; -.
DR   PATRIC; fig|742823.3.peg.2187; -.
DR   eggNOG; COG1335; Bacteria.
DR   HOGENOM; CLU_068979_13_1_4; -.
DR   OrthoDB; 9791276at2; -.
DR   Proteomes; UP000005835; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd01011; nicotinamidase; 1.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR11080:SF2; LD05707P; 1.
DR   PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005835}.
FT   DOMAIN          9..205
FT                   /note="Isochorismatase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00857"
SQ   SEQUENCE   214 AA;  23326 MW;  FDCB2E0209625E8D CRC64;
     MAQTSRKHAL IIVDLQKDFL PGGALAVPGG DKIVPVIREV LEKNSWDCIV MTQDWHPAGH
     VSFARNHEGR HVLDVIELPY GMQMLWPVHC VEGTDGAAIE GVDTMKADLV LRKGRELNID
     SYSAFCAADN ETKTGLAGCL RERGITDVWV CGLALDYCVS FTAIDAAREG FDTHVITDAS
     AAIDANGSLE KAEAAWRLAC IDVCRAEDVL EPEY
//