ID K1M565_9FLAO Unreviewed; 858 AA.
AC K1M565;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=HMPREF9699_00278 {ECO:0000313|EMBL:EKB59342.1};
OS Bergeyella zoohelcum ATCC 43767.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Bergeyella.
OX NCBI_TaxID=883096 {ECO:0000313|EMBL:EKB59342.1, ECO:0000313|Proteomes:UP000006085};
RN [1] {ECO:0000313|EMBL:EKB59342.1, ECO:0000313|Proteomes:UP000006085}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43767 {ECO:0000313|EMBL:EKB59342.1,
RC ECO:0000313|Proteomes:UP000006085};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bergeyella zoohelcum ATCC 43767.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKB59342.1}.
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DR EMBL; AGYA01000006; EKB59342.1; -; Genomic_DNA.
DR AlphaFoldDB; K1M565; -.
DR STRING; 883096.HMPREF9699_00278; -.
DR PATRIC; fig|883096.3.peg.280; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000006085; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000006085}.
FT DOMAIN 684..700
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 610..617
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 858 AA; 97197 MW; 7BF2B7B3FE19F5F8 CRC64;
MAKKETPLMK QYNTIKAKYP DAILLFRVGD FYETFGQDAI KTAQILGITL TKRNNGSDNL
ELAGFPHHSI DSYLPKLVRA GLRVAICDQL EDPKSVKGIV KRGVTELVTP GVTFNDQVLN
SKKNNFLLSV HHEKGKYGIA MVDVSTGEFM VSEGTPEHLL HIVSTFEPSE ILYQRSTQLP
YALQHKNLFK LEDWAFQFSF GYEKLTQHFK TNSLKGFGIE QMPLAITASG AIFAYLVEDT
HHSLLSHITQ VKKIPQDDFL MMDAFTLRNL EILSPNHPDG KSLINIIDHT KTPMGGRMLR
RRIILPLKVA SEIQRRQALV EFFYHHSDVT HQVQQFLSAI SDLDRLVGKL AAEKLHPKDF
GNLRESLRNI QHIRTLLLDY HDIPAWVEPL SDLSELIDYL DTHLNPELPV HLHKGNVICA
GVSQELDELR ALQQNGKGFL EEMCQREIER TGISSLKIDF NNVFGYYIEV RNTHKDKVPE
EWIRKQTLVS AERYITEELK KYENQILGAE DRIAVLEQEL YRAVAQHTLN FIDIIQSNSH
IIAQIDIGTS LSELAITEGY TKPMINESYE LHLKAARHPI IEKCLPLGEK YIPNDIFLDR
EQQQIIMVTG PNMAGKSALL RQVALVALLA QMGSYVPAQH AEIGVLDKIF TRVGASDNIS
AGESTFMVEM NEAANILNNI SDRSLILLDE IGRGTSTYDG VSIAWAIAEY LHQHPTKAKT
LFATHYHELN EMAVTFERIK NFHVSIQENK GTIIFLRKLV PGGSEHSFGI HVAKLAGMPS
QVIHRASEIL KVLEGNRTQK ENKKVKKLTE ENIQLSFFQL DDPVLEAIRD ELEKIDINTL
TPIEAMMKLH AIKNMIGR
//
