ID K1PCZ2_CRAGI Unreviewed; 1284 AA.
AC K1PCZ2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Regulatory-associated protein of mTOR {ECO:0000313|EMBL:EKC19393.1};
GN ORFNames=CGI_10008684 {ECO:0000313|EMBL:EKC19393.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC19393.1};
RN [1] {ECO:0000313|EMBL:EKC19393.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC19393.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR EMBL; JH818602; EKC19393.1; -; Genomic_DNA.
DR HOGENOM; CLU_001136_3_1_1; -.
DR InParanoid; K1PCZ2; -.
DR OMA; HNYDKAR; -.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 53..204
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
SQ SEQUENCE 1284 AA; 144585 MW; CE2A6744A54AA89E CRC64;
MSSELEVPFI NEIQEEEEEA RDWDLLIAFN ELRHREKIQG SKKVAQTWRM KERMKTVSVA
LVLCLNVGVD PPDVVKTSPC ARLECWIDPL SSQKALEAIG ANLQKQYERW QPRARYKQSL
DPTVDEVKKL CSSLRRNAKE ERVLFHYNGH GVPKPTVNGE IWVFNKSYTQ YIPLSVYDLQ
TWMGSPSIYV YDCSNAGIII ELFRQFSQQR ENELESGLNG STPRFGSPTP AVSSVRNCIQ
LAACGVSELL PMNPELPADL FTSCLTTPIR IALKWYVLQN TGRLVPNITL DLVDKVPGQL
NDRRTMLGEL NWIFTAITDT IAWNTLPREL FQKLFRQDLL VASLFRNFLL AERIMRSYNC
TPMSSPRLPP TYQHPMWQAW DLALDICLRQ LPTLLEDENA QFHHSPFFTE QLTAFQVWLS
YGSEKRNPPE QLPIVLQVLL SQVHRLRALD LLGRFLDLGP WAVSLALSVG IFPYVLKLLQ
SSARELRPLL VFIWAKILSV DSSCQTDLVK DNGHKYFLSV LADPYMPAEH RTMAAFVLAM
IVNDYKNGQD AALQGNVIAT CLEQLSDPSP SLRQWLALCL GKVWSNFDNA RWCGVRDRAH
EKLSVLLNDP SPEVRASVVF ALGTFISVTD RSDQANNIDL GVGMMLASVG NDGSPLVRKE
VVVALSSLVQ QFESQFTNVV VQWMEEEKQK EKSATVTGEV PGGWNLVSGT TALQSSNSTA
NIGASFSSSD SYSGESTTVR RTYSSSTLAG TTFSSVYMTV WKVLVQLAMG PHREVAEMAK
QIVNTLKLKA SLSARPTHVI QNPKTCYSAP SSPSNTAPIH GTPPQNHFPE DHSTPGSQMR
RDYSSPHLSG KVNSYTSPHG RGKKLLSERN SSSLIHEEKE EEPKSLKSTS VTTEFFDWSC
RHFAQPLMRL SEEQDPESSS HHRREFRFLR NNNVRQEARE EQIRAGFNRL DVEVFVNKNQ
GIPSVIKFHP YEGHVAVADK DGICFWDWEQ GTKINYIYNE NLKNTKISAM DFINPHDESL
LLCGTDDGSV RIWRNYLSEG YDGKELVMAF QAISDLIPTV RRAGLVLDWE QESGMLLASG
DVRIIRIWDS QRETKVQDIP TGAESCVTSL ASDSFGRSLL IAGCGDGSVR LFDRRLAPSE
CRVMTLREHN RWVVKVHLQK GSEGKIVSAS NAGDVRFWDP RFTESVRTLN LTQGITALEI
HKHADVLACG SPNQFIGVYN TSGDNLSTIK YHEGFLGQRI GAASCLAFHP YKVHNSSHLM
YFLVLFLWSF HNFLFDSGFL AHLS
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