ID K1PFI4_CRAGI Unreviewed; 901 AA.
AC K1PFI4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=E3 ubiquitin-protein ligase mind-bomb {ECO:0000313|EMBL:EKC20388.1};
GN ORFNames=CGI_10006104 {ECO:0000313|EMBL:EKC20388.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC20388.1};
RN [1] {ECO:0000313|EMBL:EKC20388.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC20388.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JH816429; EKC20388.1; -; Genomic_DNA.
DR AlphaFoldDB; K1PFI4; -.
DR HOGENOM; CLU_007287_2_0_1; -.
DR InParanoid; K1PFI4; -.
DR UniPathway; UPA00143; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR040847; SH3_15.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR PANTHER; PTHR24202:SF4; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF06701; MIB_HERC2; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF18346; SH3_15; 2.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS51416; MIB_HERC2; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 901 AA; 100239 MW; 88DBE1686D7DE389 CRC64;
MWSLRGIRVV QVSNSKGGDS IVGTITEVNY NEETITVFWD DGGEAVYPCT EGNHCVKILD
NAPTGVSHRG ISCTGCKESE IAGMRWVCLQ CQEVNMCSIC YKSRKHNTEH EFGRVTHPDS
SVIKVGKRKT SSCVKCRGFF PGAKVKRGPH WKWGNSNGGE EVHGVVRDIC DWGPRGYRGA
VRVCWENKKR TVEQYRVGGD GEVDLTAVKT ADGPTYYPDH LPYVDVEHVA PCEYRIGDKV
LINLSTSELR VLQLSSSCGW QDQMASCKDN IGTITHISSA SQTRVHYQNG QVFHFEKIVL
TKVHRLEVGD LVRVMRDRSI ALKLQQGHGG WLQNQDTTLG QLGRVVHIDG DGDVSVKFGD
SQYLFSPVCL DVVDPNSLSA MARVPSIPNN LHSLRLFDLT QPKQAGYLPP ITSIVKAASK
GNVEIVKEIL NNNKDKVDEV ENGVSCLQVA SHRGHEKMVK LLLERGANIN KADKDGNTSL
HFAVQGKKTA VIKLLLEHNA NVSSLNSSGQ TAIHLAIAKE QKESIKALVL APCDVHVKDG
NGDTAVHAAI STRQEALLHA VLRTHRVNFQ TENTAGYDML QWAVYKNFKS AVDVILTRCS
HCLPELVSRQ IAINGYSALH LAACYDHREC AHLLITKKPN SEKTHCYVQI ACLLVENGAE
LNLENQQGKT PLDFTCQQSR LYLERISKAA KEKRAANSGE GLFLPLHWSE MGSKGYELVC
LNRDSLEEKA EFTSVSAMIV NGLPNAEVTE IIRVQNEYLW QLYSVTKAKF TKKYGRGNEN
EVKLLHGTKS DNIFKICQEN FDFKVAGENL SPMYGKGVYF AAESSLSDHY CSEKERDGLK
YMLMARVLAG KMGCGSPEIR RPPDDCDCAV DSPSKPRIFC VFDYNQLYPE YVIKYKIKQP
K
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