ID   K1PHU8_CRAGI            Unreviewed;      1543 AA.
AC   K1PHU8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Limbin {ECO:0000313|EMBL:EKC21128.1};
GN   ORFNames=CGI_10004546 {ECO:0000313|EMBL:EKC21128.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC21128.1};
RN   [1] {ECO:0000313|EMBL:EKC21128.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC21128.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR   EMBL; JH817471; EKC21128.1; -; Genomic_DNA.
DR   HOGENOM; CLU_246734_0_0_1; -.
DR   InParanoid; K1PHU8; -.
DR   OMA; CYYISVI; -.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   1543 AA;  176794 MW;  0C625764BC85ED3C CRC64;
     MQQEGGDRMW LWYLTLLSLL VVSCRSYSVT DLTEIYQTQL SNNADNYTYN YNLHTFADNT
     SINQASVNTS SYLHTYVERG GFVLDLTHWQ DNSSGTPSNV TTLPLLKVTQ RWEVNSATAS
     PDTILVSMTI SNPGSVTANN VTVTFDLTGG LRLDISSIVK NTSSVITHTQ SNVKFQWYSS
     SITASEERFL SFVAVPSGTN GGNLEAGHNV YTSQLYFAST VLTSVAGPID LDMCVYGIRN
     VQKSIFYEQG FTALMFFIAF ALGIGLVIGA VCLFLMIKRK RAVQSKSFTQ TNLRISTRGK
     TILMDDGDVN KTGHTITDFS NIREDDSIVE VLVVKDKLKR FRELDNLDIV CTVSTDTDIE
     TQRADASLKA TAMLIRGLIF NRDISPQVYD AADKNMKQRR LLLDGNLDTE FQRQNKKLRK
     KLAAKNKAKL SRTLQRQREE KKKLVSEIAD LGDNERKQLL DMMDQEHQTE LNEEEIGTVY
     IVIESIMQFQ SESTCFTCQF NQPASCTTCS FLDKGKQFRS ISFQEFAVRR RMGMKELQQD
     QLEEVMTQGH LVGEKADWLL EEHRKVQAQM EKMYDEEVAR QRILLEEKLE KRKALAKLEE
     QQEDDGSDVL NTMASHQIEL INKAKAKKVG GLTPDEASEL IAKAKEDMIS LKERLDKDRQ
     KQEMALAKRL GDMKRKKLNQ MKSQQKSELD KTFLEFIHPL LFVETKLKLE AKHREEVNQE
     ENEIDEDHAE QLRHLNDELT DHAKDELSRA ERNLVKRIGE INTVSPDQYE KLLSEHEADV
     MRLQAQQKRE LEKQKANLNA KLAKSRRDWE QRKEQEKAEQ EEIRKREDEV VKKLISGQMS
     MSEEERDRIM KEHEKQMVKV ENSLTLNKLR QKRMLEERLA AKRALQMDKL EKKQSVEYEK
     KMRQIEHNGE ESDPENQREK LELMKLQFSQ KMAVLQGQKL NIDDELENVK IEMLKERVIA
     LKEQEEKLGA MVAALQVAKA REMALIEEQQ AAINNLKSNL IDELSERGIL SDPECQKVLD
     RHKQEQENLN KKLESQKSKQ EKELRKRLKE KIEQKEEIMS RAHKREIEAL LATSKNKTAL
     KMKQALLAHK HMMEMEKFRN NLDRQIAQTL EDVRLQFEMR RAKETQQEEL RFIAGLVRVG
     SFDQQELIDV LHILYPQKTD TEIQAVMKEI YDPNFQQAPK DVPPLSRRDS SLTERVRSNQ
     SQELSRRASL SSRFEDSNRG KAEKKSSFKK SRRQSDLDSD SFSRPLPNIP KKKKLQKLDE
     NSESDNEYSY LSKRPEPIGE VVEARRLEDF DETLPASGLP SKLPPLEAKA PKKGRKKKKK
     MLFWTILCLA VLSCQSLGAD QTSVVDEFND ALEEGLQSVR VLIQNTESHL PSAVNKAFDY
     FNRLQDKPNG VAEAANALYE TAKNTVTQVS AETEAIFSKL SVLTDQPRLP QNILQLIADH
     HNLQDFLIKE AREAFSQTIR THHLGSSKAD EKLASFLQQK TNAIKQAVTS IASAVHDVIG
     HLQNSANSSL SKEAVENILR SGMETLGFAI VFAQEEIKDA MSH
//