ID K1PY04_CRAGI Unreviewed; 173 AA.
AC K1PY04;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=N-alpha-acetyltransferase 20 {ECO:0000256|ARBA:ARBA00039529};
DE EC=2.3.1.254 {ECO:0000256|ARBA:ARBA00039120};
DE AltName: Full=Methionine N-acetyltransferase {ECO:0000256|ARBA:ARBA00042723};
DE AltName: Full=N-acetyltransferase 5 {ECO:0000256|ARBA:ARBA00041220};
DE AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAA20 {ECO:0000256|ARBA:ARBA00042743};
DE AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAT5 {ECO:0000256|ARBA:ARBA00042702};
DE AltName: Full=NatB catalytic subunit {ECO:0000256|ARBA:ARBA00042295};
GN ORFNames=CGI_10010634 {ECO:0000313|EMBL:EKC26513.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC26513.1};
RN [1] {ECO:0000313|EMBL:EKC26513.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC26513.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
RN [2] {ECO:0000313|EnsemblMetazoa:G10852.2:cds}
RP IDENTIFICATION.
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EnsemblMetazoa:G10852.2:cds};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] =
CC CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-
CC [protein]; Xref=Rhea:RHEA:50484, Rhea:RHEA-COMP:12694, Rhea:RHEA-
CC COMP:12695, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133356, ChEBI:CHEBI:133358; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036044};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA
CC + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein];
CC Xref=Rhea:RHEA:50480, Rhea:RHEA-COMP:12692, Rhea:RHEA-COMP:12693,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133045, ChEBI:CHEBI:133063; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00035918};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] =
CC CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-
CC [protein]; Xref=Rhea:RHEA:50492, Rhea:RHEA-COMP:12698, Rhea:RHEA-
CC COMP:12699, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133361, ChEBI:CHEBI:133362; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036121};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA
CC + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein];
CC Xref=Rhea:RHEA:50488, Rhea:RHEA-COMP:12696, Rhea:RHEA-COMP:12697,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133359, ChEBI:CHEBI:133360; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036101};
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex
CC which is composed of NAA20 and NAA25. {ECO:0000256|ARBA:ARBA00038748}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. ARD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00025786}.
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DR EMBL; JH818869; EKC26513.1; -; Genomic_DNA.
DR RefSeq; XP_011416204.1; XM_011417902.2.
DR EnsemblMetazoa; G10852.2; G10852.2:cds; G10852.
DR EnsemblMetazoa; G10852.3; G10852.3:cds; G10852.
DR EnsemblMetazoa; G10852.4; G10852.4:cds; G10852.
DR EnsemblMetazoa; G10852.5; G10852.5:cds; G10852.
DR EnsemblMetazoa; G10852.6; G10852.6:cds; G10852.
DR EnsemblMetazoa; G10852.7; G10852.7:cds; G10852.
DR EnsemblMetazoa; G10852.8; G10852.8:cds; G10852.
DR GeneID; 105320105; -.
DR KEGG; crg:105320105; -.
DR HOGENOM; CLU_013985_7_1_1; -.
DR OMA; GHGENWH; -.
DR OrthoDB; 5471170at2759; -.
DR Proteomes; UP000005408; Unplaced.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR45910; N-ALPHA-ACETYLTRANSFERASE 20; 1.
DR PANTHER; PTHR45910:SF1; N-ALPHA-ACETYLTRANSFERASE 20; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005408};
KW Transferase {ECO:0000313|EMBL:EKC26513.1}.
FT DOMAIN 2..152
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
SQ SEQUENCE 173 AA; 20122 MW; 98FE344C06E56966 CRC64;
MTTIRPFVCE DLFRFNNVNL DPLTETYGLP FYMQYLARWP EYFQTCESAG GRIMGYIMGK
AEGGGEKWHG HVTALTVAPE FRRLGLAGKL MNNLEQISEQ KKCFFVDLFV RVSNKVAVNM
YRKLGYEVYR TVLEYYSGDV DEDAYDMRKA LSRDKDKKSM IPLKRPVRPD ELD
//
