ID K1Q0W4_CRAGI Unreviewed; 2113 AA.
AC K1Q0W4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Calpain-7 {ECO:0000313|EMBL:EKC22455.1};
GN ORFNames=CGI_10002257 {ECO:0000313|EMBL:EKC22455.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC22455.1};
RN [1] {ECO:0000313|EMBL:EKC22455.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC22455.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; JH816974; EKC22455.1; -; Genomic_DNA.
DR MEROPS; C02.029; -.
DR HOGENOM; CLU_232212_0_0_1; -.
DR InParanoid; K1Q0W4; -.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19756; Bbox2; 2.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF04212; MIT; 2.
DR Pfam; PF00648; Peptidase_C2; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 4.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 2.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 2.
DR SUPFAM; SSF116846; MIT domain; 2.
DR SUPFAM; SSF101898; NHL repeat; 2.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS51125; NHL; 2.
DR PROSITE; PS50119; ZF_BBOX; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 2113 AA; 240507 MW; 8B0394FEB6523DA7 CRC64;
MDPKRSAQDA LRCNLCDTPN PQYNCDICHI NLCKMCAGEH LLDESKEHKV VQIRQRSYGP
DYPTCLKHTK KQCELHCEQC DLPICTHCVS SDVHLGHKAI DIMKIFDTKK EILKNDFEEL
KISLIPKYHE VAATILVQKA ELENHSKSLT TALCKRGEEW HSEIDEIINK RKTEINQMQT
MYLAALNKQK TEITQSISLI AKRIINLKKL IDSNDVYAVS AYKSKNDSFR KLPPYLRAIF
PCFSLNKIDT EYLQQQFGIL SAFSIESQEY HFKMESSEAA SPSSDICRGP LLNQPKIITT
INTNFKHIFS VTCSTDEQIW VRGDSNIIKL YNLQGELLES IRTKSGNDPR DITVSKSGHL
VYSDFDERTV NIMMNKQISE VVRLRTWRPL RVNSTVSGDL LVTMVGDKNK RTKVVRCAYS
PENQTFLFDS KAPPLYFSPP HRSINYVSEN KNLDVCVVDG TACAVVVLNQ AGKPRFKYTG
PPWFTKDLFY PISVCTDSQS QILIVENAYD CIHILDQNGQ FLQYIDNCDL HEPYGLCVDT
RDNLFVTECT IDCNLQVHCN YKTMDPRKCA QEVLRCKLCG TSGPAFYCEV CRFYICARCV
GNHLLDESKD HKVVPFERRK FIPIFPTCSK HTPKQCDLHC EQCNIPICTR CVSSYDHLGH
KADDIMITFQ RKKEILQQDL EELENFLPKC HEVVSKIKHQ ITTINEGFLE LSNEIEQRGK
DFHREIETII ERNKSEIINM HKKYLAAMEK QEKQINNVIA EITHNISDLN NVLDSDDFYL
VSAYNSKKDS FQSSIPKLKI TFPSFCIQYI NKEQLCEQFG SLSSGSITTE HCDLIEHPGV
TSPPLDKPLL AQPKNLSCTN TGYCCLYRVV CVSDKRMWTI GNSSFIKLYN IQGELLDSIK
TKSWNVPSDI ALSVSEDLVF TDYYDRSVNV IKGNRIEKVV KLLTWRPLNV CSTLSGDLLV
TLIRDDKKQS QIVRYSGSTE KQIIQFDDEG KPLFSTAQLG AICENRNLNI CVIDIEACAI
VVVNQAGKLR FKYTGPDSES TSEKSFDPVG ISTDSQSQIL VADYDNNRIH IVDQNGHFLC
FIDKCDMRHP YGLYVDVGDN LYVTEFDRDI EACAVVVVNQ AGKLRFKYTG PDSESTSKKS
FDPVGISTDS QSQILVADYD NNRIHIVDQN GHFLCFIDKC DMRHPYGLYV DVGDNLYVTE
FDRGMDDDTS GLVDPAILET DGKQFAYQAV EYDKTGNYPM AVFYYNEAAQ ALLSAALAGS
KLPNIINKAN EYILRAEELK KAINSGAVVT QTSEHKSKEK LDMERGNFLL HQAFDEDEAG
NLNEAKELYT EAVEVFLKIR DGTSDKGLQE KMTKIASQAL DRAEDIKKKL SASSGVKPLP
PLNKAGEYHK PPPLGYGAFL DDDDKASLPA GKPSTANNAP KRSGHLINLG PTVYSREEIE
VLRKTSFING REYVPFMSVD MKEKFAYPVP YSDKCGKLAL SPKQRADLQG WVRPEQFCDN
PQIIYTVSCY SIKQTIVSDC SFVSSLAISA QYERRFKKKL ITRSVIIDDF FPMGRGGELL
CSFSNNKNEL WISLLEKAYM KTIVSDCSFV SSLAISAQYE RRFKKKLITS IIYPQNRNGD
PVYNPCGKYM VKLNINGVPR KVVIDDFFPM GRGGELLCSF SNNKNELWIS LLEKAYMKVM
GGYDFPGSNS NIDLHALTGW IPERVAIKRN SEDFDRDKEF KRIHDRFHKG HCLITIATGE
MHDSEADRAG LVPTHAYAML DIRDVKGKKL FMLKNPWSHL RWKGNFSEKD VMNWTPDLQK
LLNYDPKSAQ QYDNGVFWID YDSLCRFFDV IYINWNPELF KYTTCTHSTW AAKEGPKRDS
YNISDNPQFR LEIRANQPAA VWILLTRHIT DKDDFADNKE FITLLVYKSE GKKVFYPYSP
PPYKDGVRIN TPHYLCKMVE EKGTRQFTLV ISQYEKNNTI HYTLRVFSSC EFSLNKIVDP
YKKQYEKRVN GQWKGRTAGG CGNYRDSHPN NPIYQFRLDN SHTDNYILLE LLGPKQYSVG
FEVTCVSENV PGAPGQFKKT SSGDYRNGYC VLQLDRISGG VYNVMPSTFL PGQEGPFFLD
ISSAGPVTVA QIQ
//
