ID   K1Q346_CRAGI            Unreviewed;       786 AA.
AC   K1Q346;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Caspase-10 {ECO:0000313|EMBL:EKC25819.1};
GN   ORFNames=CGI_10003352 {ECO:0000313|EMBL:EKC25819.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC25819.1};
RN   [1] {ECO:0000313|EMBL:EKC25819.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC25819.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   EMBL; JH817531; EKC25819.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1Q346; -.
DR   HOGENOM; CLU_356886_0_0_1; -.
DR   InParanoid; K1Q346; -.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 2.
DR   Gene3D; 3.30.70.1470; Caspase-like; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF8; CASPASE-3; 1.
DR   Pfam; PF00656; Peptidase_C14; 2.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 3.
DR   PROSITE; PS50207; CASPASE_P10; 2.
DR   PROSITE; PS50208; CASPASE_P20; 2.
PE   3: Inferred from homology;
FT   DOMAIN          17..151
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          265..304
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
FT   DOMAIN          382..512
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          663..702
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   786 AA;  88451 MW;  55E071A614DA5B4C CRC64;
     MAKKEEDFYQ FDPERTHQGL ALVISNFTVG RRKRKGAEAD LKYMKKTFKR LGFKVDCHEN
     VKGSELVSIL NKCSQQMLTS YDCFVFAISS HGMEIVQEDK SGNSVHQHAI EMFDGVYIYT
     KGILDYFTDG KCKALKNKPK LFFIQAGVGF DSGISTHNKK GGQDQRTTRD KTDFEGFSGD
     TETDSDRESD VSDTDVEEDE SSLSDIEPTA TGHGNASGVT GDIEDDIDAK RRRLYESRGS
     GDDIDPPRGQ RIYPPAPAPV EFTLVPCHND MLIMFASPQG HYAIRNKTYG SYMLQLLYKF
     VEKYYANGGL TQNQTNFLDV LRDVTTQMSQ MEFMGSKEYT IVPCVVHKLR KDVIFTQGKN
     MGSTKFTIMD ADIDTYQFHP KRTHQGLALV IANFTEGEDR REGAGSDLKY MKKTFKRLGF
     KVDCHENVKG SELVSILNKC SQQMSTSYDC FVFAISSHGM EFVQKDKMGN SVQQHVIEMF
     DGEYIYTKDI LDYFNDRKCK ALKNKPKLFF IQENLLIWFS SGAILKCRIP ETKSTHDQYD
     AGVGFDPGIS THNKKGGQDQ RTTRDKTDFG GSSGGTETDS DEESDVSDTD VEEDESSLSD
     SDIEPTAKGQ GNASGVTADL EDDIDPAKRR RLYPLESGGS GDDIDPARGR KIYPPAPLEF
     TLVPCHNDML IMFASPQGHY AFRNKTDGSY MLQLLYKCVE KYYANGGLAQ NQTNFLDVLR
     DVTTQMSEMK FMGSKEYTIV PCIVHKLRKD VIFTQGKSMG STKFTFKLSE IISTLGMSFF
     TWSNKN
//