ID K1QI33_CRAGI Unreviewed; 2828 AA.
AC K1QI33;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=G-protein coupled receptor GRL101 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CGI_10009718 {ECO:0000313|EMBL:EKC30834.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC30834.1};
RN [1] {ECO:0000313|EMBL:EKC30834.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC30834.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; JH818778; EKC30834.1; -; Genomic_DNA.
DR HOGENOM; CLU_226747_0_0_1; -.
DR InParanoid; K1QI33; -.
DR OMA; AYHEFES; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd15137; 7tmA_Relaxin_R; 1.
DR CDD; cd00037; CLECT; 2.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 2.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 4.
DR InterPro; IPR031569; ApeC.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF16977; ApeC; 2.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM00034; CLECT; 2.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00130; KR; 2.
DR SMART; SM00192; LDLa; 4.
DR SMART; SM00473; PAN_AP; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 4.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 2.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS50070; KRINGLE_2; 2.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS50948; PAN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 287..360
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 535..692
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 702..791
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 898..1021
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1042..1168
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1631..1888
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DOMAIN 2280..2353
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 2360..2449
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 2459..2536
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2597..2720
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2741..2803
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DISULFID 1190..1202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1197..1215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1209..1224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1233..1251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1514..1526
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1521..1539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1533..1548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1551..1563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1570..1585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 2828 AA; 321627 MW; 6EB97203A1E45DBB CRC64;
MKQVCPFVEC QNGGRLVQTT CQCDCPPKYY GFFCQNNYKR SLWPGGTYAL PTSMFGCPET
EAKGWSISYV NLTLPESSQQ QEWNMKNPGP LTDVIEPNIL GPYHYRALQM NFCVKTPTYF
EDKEGNMTST EWPKGQYCLY NFNGSCPKDF TNGTMTIRGY QFTEQDIGGQ IPGNKGQNQT
LLLQFCCRED GNHLTPIQLP KEFPFIMFQS QSADRCQEIE SMTSQRDFFY MTNQNNNWEF
KGALPMFDTT TLKNSVGVPY CYYIPYDHIF NDLHSERREC YYESDIGNSY SGRANVTATG
RGCLQWTGSS DSFYKNDRKA YHEFESNYCR AYEIGSYKTN EPVCLVQHPS TLRSCGIPKC
GKDRDLKEFG KFKPFRSVPH YNTMKPEYAV DGSIERHNTM SLTTLNMQDF AGNLKSLVTD
RPLLKPWFQV NLQEFVEVHA ILIYRSVTNF PNNVRYFGTY VSKNPWDFMN YGAVRCDDLR
FPGYSRVFRY QCRRPVIGQY VTVRNFDFSH PGSKPGIFYR MEINEMVILG KSTSCGRPLG
MASGNIYDYQ LEASSEDAEG SVVESMALAH RGRLYNPNPG WCSSPEDDSP WFLIDLITPT
IVQGLMVQGW TSGKDSKYIR SFLVSYGTEK KSLRLYDDIP GTVKTFVIDV SAAVITPQTF
IFHHEVLARY IKIIPDTTNG QQACLKAEVI GCQKQLQRDI QCKEESMDFG FEELRRFSFW
LNGSPYILYN FTSVDDCRQF CLSNGCTSLN FKDYSAGKTC SLFDGDRYHP TRQSALVLTG
SSLTYASHRL CFSGVTKPNR CNFFINLTKE DEAVIRSPGF PFSYGQGLNC KWTIDTGTSK
FVKLEIVYLK LAKPTTVLDL NKLGMFDVNP GKCKDSISVR DDSNTFTITA DTEDKPGCGM
LKEGCTIRCQ IPSAYIATDR FPSPYQPGER CIWRIDGKFG QYVQLNILNI DVINGGASCA
SSYIAVYDID LTHKERLLGR YCKENRPYSV ISSKWHHMRV EFRAAPDQRQ GRGFLAEYSF
VDFTQTLSSI TNEDCPVGWH YNDNSCYNIF TNDVGITWPE ADRKCNQQNG SLVSIASKQE
LEFVHFLVTT YINDIADRKM FIGLRKVYSG DKKQLEYFWS DGNPLTFTAW YRDDVIMNRQ
PNGLYNEKCT SISFFSIYSM NDWHDTACAY DKIRSYMCEI DISNTKGARC TDTQFRCGDG
GCISLSLLCD FVAHCKDGSD ESSCIGCEHG FECYDQTCLH PSKVCDGFID CNGFFAEDES
QSCENNIRKS CKDWWSLGRR ENGEYLVSLS LEGKKHTKVE CRFNISEQTV TVQTIIHHNL
EETIVANTET IDTALRYAAT KKQISNLKKD NKCSQSIRVR CHYTNNDQDN IWIGDNGKQF
HTTLGESTGG CSCPFVNKCE EGKTKCNCNS TVGGWYRADF TEVREDFGVI TDHSVLPIRS
IFAIRPTSVD RFVKLDVGPL ICSDETYAVS DDFLCRSGKI VPMSQRCILD YDVYGDVSGC
RDLSHLDDCE FNQCPTGFLK CPNSFCIPPR LVCDGHKQCK HGVDELLCES CPGLYRCRNS
TICLDPSKLC DSIPHCPYHD DELLCNIEYP KEFQECLPHP NEFSSCDDLM KNDVLSAFLW
IIGFSSLLGN LGVFVFKVFF DTDTLKKGHG IFITNLSISD FLMGVYMIII ASADEYYRGR
YVWNDLIWRR STTCRIAGML ATVSSETSVF LLCLITLDRL IAVKFPFGQF RFTKRKALIC
VAVVWSITIW LAVIPLIPGS YFQGEFYSRS VACLALPLTR DRPAGWEYST AVFIILNFLL
FVTIALGQCL IYREISQTSS SVKSTRRNQD MAIARGLFLV VLSDFLCWFP IGIMGLLAIS
GQVISGEVYA WVAVFILPIN SALNPFLYTF ANVRKKVETR LSSNKSSNNR ATADNYADVC
DNDSFIIGKH APLAVTLADR MKTNPLTVDE MKLVVLRLAE AMKFLHERDI VHGCLDTSLV
SLDIVEGKIK DLALKIAPKT ALEDEEIPND IKQLGEITLS MLDTYKSTNM QTYYKRSLWP
GGTYALPTSM FGCPETEAKG WSTSYVNLTL PESSQQQEWN MQNPQLLNDV IEPNILGPYH
YRALQMNFCV KTPTYFENKE GNATSTEWPK GQYCIYSFNE TCPLDFTNGT LTIRGYQFTE
QDIGGQIPGN KGQNQTLLLQ FCCREDGNHS TPIHLPKEFP FILFQVYIAV LSQSADGCQK
VESMTSQRDI FYMTNENQDW EYKGALPMFD TTSLNNSVGV PYCYYVPYER RECYYESDIG
NSYNGRANVT ATGKGCLPWA GSTEPFYKNT RKAYHEFESN YCRAYEYYSY KSREPLCLVA
YPSVKESCGV LKCVQRDMRC KNTSVDFGFE ELRRFSFWLE GATFSVTNIT TIQGCRQFCL
ATGCTSLYFT EYSDSHTCSL NTGDRYHPTR QPAWVLTGSS LNYASHRLCF SGVMELNRCN
FFINLTKEGE AVIRSPGFPF RYGQGLNCTW TIDAGTSNFV KLEIVYLNLA KSTTEIELKE
LGIFDVNPGK CKDSIIFKDN SDTIQITAET QRDFRDSIII TTGPTLSITL QTCFQYAKWD
QENILEVKAF RAEKPGCGMS KSGCTMRCQV PSAYIATDRY PSPYQPGERC IWRIDGKFGQ
YVQLNILSID VINGGTSCAS SYIAVYDIDL SNKERLLGRY CKENRPYNII SSKWHQMRVE
FRAATDQKQG QGFLAEYSFV DFTQTLSSWT HEDCPVGWRY NNHSCYNIFT SEVGITWPEA
NRKCIKQNGS LVSIASKQEL EFIHSLVTNN LNDIIDKKMF IGLFEHLLFL RFFSITNVGE
YEFGVEEM
//
