ID K1R4D2_CRAGI Unreviewed; 2087 AA.
AC K1R4D2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0000313|EMBL:EKC38384.1};
GN ORFNames=CGI_10021757 {ECO:0000313|EMBL:EKC38384.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC38384.1};
RN [1] {ECO:0000313|EMBL:EKC38384.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC38384.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; JH816985; EKC38384.1; -; Genomic_DNA.
DR HOGENOM; CLU_227958_0_0_1; -.
DR InParanoid; K1R4D2; -.
DR OMA; EWFIASM; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 92..595
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1096..1216
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 2087 AA; 237646 MW; A790B3352BD961CC CRC64;
MTFLLKLSNP GTKPCYVWQM GDSQPRTIYG DTFCEEKAKL NAYVYKPWNV SNEIRHQHMY
RSNGTHNVNV FGFNLVSTQH IYDIGVITGA NCFYPNVHII GGGQRIDEPV NRFRSEWINL
ESSAEINCPA SKGPEYHWKF FKITEGNTYL DRVFSPYNIS TNATDHFKIL FEPNTFQPGL
YSISLNVSMK DIPGMFSEHY TYLNITKTPL VVRISGGTAR NIGYDSKLIL DAHQMTKDPD
SDKTSNFTFE WRCRQENEVY PPTLNYITLP TLDEALNQTR RDGCFGTGIG KLPTSSGSFE
ISTLLLEPHS SNVFEVYVRK DTREGLFQQT VEVIDGDPPL IQIVCVENCN SKMNPSSSFS
VQGKCLSCNL FEKVQFEWSL FIEEMDEFKI VPHFDSFLVT DTTSSVLVFE SSTLTGGKTY
RLRLAANIYG YSGSFTEYEF ITNLPPYGGT CGINPSSGYA LETEFVISCN DWVNPGEEET
KGAGLLYRFW SKLRGRQDTQ LLYYGTDPYT PDTTFPLGPE ESDFLHDVVI RIANPIGEFV
ETWLSVKVSK PVVKSDVNEL ITLSSGQDST LNGLLSSGKT QEAKQVIVAI ASLINTSPTE
IGISRASVIK DVDTVLTTTT TTTTTTTTVP SASSSLSDSS TFAEYDNFTT FMPTVSSTTK
KSTTGKVTTP ITQLPTTRES LSTYFVGTTL DPAEVEAERL RKEEEEKQKR IKLRESLLTT
LSNETSSLTL DSLQQTALCF RVVTHESSEL SETSQNLAVD AISDVANSFQ KIIRQSQTDS
TVQTYSAAED ILATLSSVII AATGKELAEI QKINEEDGSL GDEGSSDQVR ALASKVFDVA
EVVYKTIIQD RVPGEPPVVL ESQLFTMVAE RLTVSDVNNT YLDTTTGSFQ MPTMDSILSE
NTSFVDSKLT YEVPDLHLKE ELEHTIFLPP EFVQENGIGA YYLGVRPVYN ETDEEEYINY
DDYYVDYGIV TPPDLLNYTI SFVTSGCFYW NIHLEQWVTN GCQISYLSNS NYTRCLCNHL
TSFGSDFFVP PNTINFMTVF NDFEAKLRDN WAVLAVLCFM YLMYMIGLIW ARFKDKRDVI
KWGIAPLADN VVCDKFFYQL TVCTGMRRGA GTKSKISFVL AGDSFDTGVR ELIDEKGIKT
CSRGSINNFV LSTSEWLGPL TFIRIWHDNS GEGKFQGWYL SKVIVTDLQT SETYCFLCNR
WLAVEEDDGM IDRLLPVASK EDMTNFQNLF MTKTKKSFTD SHLWISVFSR PHRSTFTRVQ
RLSCILSLVM TTMMVNAMFY QAEDRVKNKE YISFGPFEFS LSGIYISFVS SLIVLPVNII
IDQLFRKSKP KVNRITNAFM GKNVQPLAAL SHIKLRPRSP PDSTKLEDFV EKPSTRPDSA
NSTYSMHSES ALIEKRKKSN EIAIISHPQT KPQKKKTKKF MLPHSCVYFA YSLVYISAFL
SSFITFLYSI EWGKEKSLSW LSSILMSIFE SVIVIQPFKI IIVAMLLSII LKRPDIEEET
ETSEDSQMTN QLLPDEEMLY KNPVKSERPA LKIEPPDKEK LAEAREKRMK EIAMFDIVRE
IAFYFVFVAL IVLVASHNRD KKAYSVKEAI DHIIDIKKIN NVEECKAVPM MYKFVESCSQ
EWSVTMEDDA TYLEGWNAPV VKNSTMLINY PWKHRSLFDD AGLPFSGEFG VYTGGGYVAD
LIGDRDRAMK IAYGLMLNNW INQYTRAIFI EFTVYNPYVN MFSNVFIAFE MPTMGKMLIK
ESVKTFRLFS YLGGYGVFVV LCELATLAIV IYFIVREVRI IRQQRKKYFK CFWNCLELFN
MICAVVSVVM YIVRHMITQL AMQSVKKLRD KFYNFRKVAM WDEVFGYFMA FTIFVSIIKL
LHLFRFNKRM SMIAGTLKYS TKELSAFSVV ITILIVAFAS WGYIMFGPKM PEYRNMFQSF
ETLLAFSLGD FDYLALERVN RVFGPIYFFT FILCIMIILL NMFVTILNES IAAVKSDVSK
QSNEHEIVAF IWCRFKDWVG IDFDKIFAEV KRKYMLDGNN GSKDKEKTED IEERLRDISK
RLEKLGSCNS AKIHHPPPDM KPMDDTTKEI LFTRLFPTVR HQAISFH
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