ID K1R4P4_CRAGI Unreviewed; 5054 AA.
AC K1R4P4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN ORFNames=CGI_10020838 {ECO:0000313|EMBL:EKC28906.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC28906.1};
RN [1] {ECO:0000313|EMBL:EKC28906.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC28906.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|ARBA:ARBA00025162}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. ROCO subfamily. {ECO:0000256|ARBA:ARBA00008171}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; JH817222; EKC28906.1; -; Genomic_DNA.
DR HOGENOM; CLU_223326_0_0_1; -.
DR InParanoid; K1R4P4; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01833; TIG; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM01225; G8; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS01176; IF2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 5054 AA; 564219 MW; 71A5FF8762A8FC6C CRC64;
MVTEYNPNYD FVAAKYPEQQ LNELNRNRLE LVRALGQGAF GEVYKGYILG FPNMEREMAV
AVKTLPAYST EASELDFLME AVIMSKFNHP NIVKLVGVCF ESHPRYIVLE LLEGGDLKTF
LREMRPKTVM GDPLVRVSDL LSLADDIAKG CQHLEERHFI HRDIAARNCL LTCKGKDRVA
KIADFGMARD IYRSDYYRKG GKALLPIKWM PPEAFLDGIF TSKTDVWSFG VLLWEIFSIG
YMPYPGRTNH DVMQYVTNGG RLEPPEKCPK PLSVKGDVSV TIAGTVCDVN SVSPTQITCV
TNQHKKSEKA NVRVEVAGNG RAMQSSAEFF YIDVWSSPFT WGGGPLPKEG DLVVITPGQT
ILLDVSTPKL TLLLIQGGAL IFDEKDIELK AVNILIVQNG LLQVGTEKEP FQHKAEITLY
GNHRTKEYPI YGTKSLAVRE GNLELHGKPV PVTWTTLDAT AYAGNSTIIL REAVTWKAGD
KVVIATTSHR HSQKETELMV IQSVASDNRT MTLTQPLKYE HLGVTETFDG TDVEFRAEVG
MVSRNIIVRG DSNPDFVEKI EACPDGFDTG EFATQTCFQG RFGEEMGSDQ FGAQIMIHSP
KNSGSMSHAR LEFVEVTHAG QAFRLGRYPI HFHLNGDTNG SYVRGCGIYN TFNRAINIHG
SHNVLVEYNV AYNVMGGAFF FEDGIETGST VQYNLLMFVR ESSSLQNDDI TPAAYWVTNP
DNTIQHNRAV GGTHFGFWYR MHVHPDGPSF DSSICPQHIP VRVFRNNTAH SNGWFGLWIF
TTIKTRVGGG CGSSTPAMSL FESLTAWNNE KGAEIVNGGA LECRDFVLVN NEKAGYEGKL
LIEGDQLFKD LLIVGHAPSL TREEQGCTRA GFILPYGNGL TLDGIRFVNF DESNCVGVDF
ARIDGTCKVH CGGFYYETKN LKWVSAPNKG TYPWPWAGVL KDLDGTLIGE TGDPASIAAN
VGKSVISASD TLPPTCVSFP KFSNFNGSTP ARVCPPGIKY HRFSFNGISP SSLDFKDFVF
KNRYGNDSVP WRKKAITHKL GWMMNNSGGY EYVIMRQKVS RRPDRFFLDG STNIEPTRNI
DGNSEYGQWE YLPTDSEIKY IISSNKPASR RRRSVADFND YGVSFRAYKC YYVDCKPPVD
PNTVPPVTSR PYDFQYWSES DTWASGNLPQ DDDNVTIGKD QWVVADTALP RMGKLVLYGV
LELDDANGTR NFELNCTYIV ILGGRLIIGW PDKPFLGQAL ILLQGEHSTP YFRTTSGPPL
GSKAIGVFGG LDLHGKDVGT SWTLLAQTAN PGNSQITLAT AVTWKVGEEI VIAPTDFSIW
EKETFAITAV SNGGTTLTLN STVQFKHIAH TETAGNESMT MAAEVGLLTR NIRVEGASYN
KLYSQSFGAR IMVSQTQDPT DSNRLLVGYA RISNVEFYHS GQEGWVAPFD GRGSIAYIDA
GTVSNIKPSY VKKCAFHKGF SPAIMAYATN KLPIEDNVIT DTVWFAVEAM GDGSIIRNNF
VTKVQWEGSY QGRRESSNFR YNGAFNLDKA TNLVLQNNHV GGAERLGFRT TGEPCDVSSA
DSWTGNVAHT ALVGVGLLTI NPLPGYLKQC TMYSNFTVWK NFDYGIFYQG TASSSVRNLK
AADNGVSVFQ FVEGPPSLSH RFQDKYANVI DSLIIGTSDE LNCSTARGDR SDFNFIKSRE
KIKSHSFPLR VGVTMPTFTS GGNACPNMPC SGIMSYQTIK GIFRLQDVTF SKFSNKCNSQ
GDRAVAPNKE NDDGNHPFIT ERIQFHNMAE ENKILYWRSD IGKIDSSNCV DMACDAKVKC
LLQDLDGTFL SSPGFVIPQS EHEWNGNPKM GLGDYRIPKE MLVRSNGSRI PVAEIAPHKG
IIRSSCQYKS AWQAYECHQL NYKTLVIESL DADTETRRLS PVAILGDGYL DLINGPQDHG
WCSGYTCRKR LSTFQAIVAT EKEFLLHYTS TSPQKSRFFL LDANPNDCIV LSVWYSKPWR
LDVYHDGNFI LPPNARFEGA NRKYVVDPPP VGQPDYYKPN VTGCALKSGT SYFNRDTGII
TLMIKGPAPV RIVTVKTVIV SFQLPAMPEN EFYGENIIMN LASFLNIDAS RVRITKIVRE
TSSVSGRRKR ATGRITGVEI EISNPPSQEL NTTASAGDLS TEELQNITTT IVNDVQAGST
LLNLLNSTGV AIAEPPPDPE DPNWQVVLSD TNIALQTLAQ PSEMRLSITI VPLHEGAPFS
TQPKLQIYDS SGTVIDKLGT NINPWQITAS IVSGTGNAAG QLTGTTTVPY QNGWANFTDL
AISHFGDDYG LNFTVTYPAG VNLFTLTNFS LPRRPLKVNA MSIPTTVVAN SSISLVIKLE
DAVTSQIIEQ THWRITDWEV CVTLDGLEFY KGKQFGELNT KFNATTGLAT LSDIRFTEPG
MVILKIGVTS VPAEYSLETQ LLINIRRADL YASSSNSSAQ LLQLRFEADY NSIVAAGYQL
QFETVIGNFL IRRYPDIDLD SVQIDSGGVT ITYQITSGGT LQTNGTLTLC DALDDGTNQV
WRTVIEDKDL AKHIENKDQK ISNVKVIKKL CKMLGVVPKI PSKERLRQME EASQQMETPR
RPPPSPKELV PRPPVITIMG HIDHGKTTLL DALRKSNVVS EEFGGITQHI GAFTVKTSSG
DDITFLDTPG HAAFTALRER GAIVTDIIVL VVSADDGVMP QTIESIEHAR KYNVPLVIAI
NKIDRPNADV ERTLNSLLEH GVQTELNGGD VPAVPISALK GENISELQDT IAALAEILDL
RCDVKGEMGG RIIESKMDTK IGLVATVLVQ RGTMKIGTMV VAGEAFGKIK KMINNQGQAV
RTVTPSFCAE VYGWRELPQA GDEVIEVKSM RKAQELITIS AADRKAKEIE KYIPMIERQQ
EEQKEIRKKL MEVKAESFFK FILARRKITK DGDLPSTLGE CNLPIVLKAD VCGSIEALLE
MFSTFDSQLC ELRVVHHEVG PVTEADVNLA ESLNAEIFSF NVPVSEDLRR KAEQANVVIK
ENNVIYTLID ELNESANSRI PPFMEEDKKG EAEVLQVFEY KFRDTRRMVA GCRCTQGNLQ
RKLEYKVLRN GEEVYKGKLD SLKHHKDEVD TISSGKECGI LVSDEDFIFE QGDVIECFDW
KVVKKTESIR GKCLPTFPEV KKASLWNNDL GVVGGLESVS TYPRESTGER DLWLKRRLKP
VSAFDIDYEY HYEYKANSVV LGKFPVVTIA KTLHYTNTGV IEYIRADDKV IIQNKNKQKK
QERSKIHGMN RVLPLATELK VKDSIAAKKG ENITQDLTIQ HFLQNKDVNE TDLFRIFFHI
GKIEAPTLEF LEAVERLCLE PYHSKITHYT ELQSKRRPHR SVDRNDRELH NYTYSKMVLI
HALGNTGSSR DHLLTYMRPG EGDNSWRRAA ILAMRHFGCV ESSTALFNLV VNDDHSVVKQ
QALEMFENHP LSNKSIPEHR DIILSRFYNY KTLMRTKRGI LDVDLKDGFF FSLKLPGIQW
TKQVGNDALG AAFGISLTNE LEIEIKPLSS HAMINMYENA FAKVMVGWFK VEQLYLFRAH
ACYRGHAGYD IHILKDFGIN GTQDLAMIFD RIVKTVIDPV LSKVKAFKTL IQSYDNKVDA
VMEVVEYGGT PWIDQIKKIA TKIRYFVEDV KEDITNFYST IVDAVTVTLP YVGKNLFDSV
AAIISALKDF LTNPVQSVTI FGKSVLDIKL ALGIFIDVKN KMIETLSYLK GGTSFWIDYW
EDFKEILGDI QDLFRLIFKR RENIPAINKK DKLSTALTDG IQMTAEQTNM IIDSIKKSFG
NFSTEFKETF DEILSPFVNS FYSMFNAVKA VKSGYMSIRN TYIKIKNVTQ KIFGSKFHIT
FPNHRRRQDS TCGLGVWPTN QNERYQTLGV DVQVTEFSDI RCPVNGEVFK ESNRVLILPT
DEDFIDYEII IENIIPESNI STSGQFLIAG KDIIGKADKS PCKRNCIHVS VRKKSPIQIR
DSDYEYIDPS PFLDHLLPSP RWIWDCRDYT YMNVLNVVSA DATGEVLEKV NKEIVRSNFG
EDKMNGFPPI EPKYRPPDLE VANRSDLFAV TALEKFTNGF KSIVSQFTDI AKQLFDFSNN
SMAVVNVRRG NRQKRETVEN CLVKQITGRN HKDPAYELQV AADDDKSNLK LFYAIGTQQG
GTNVLDFTEM GGFSVFVATN DLPNGIPLYW TVKAVNSQGS DARVYCMLHT YDNTLPDGRV
DPSYKYSSHP NVLLGTITVF DDSLLKHTHM QAVGISSGMY GSEIISWKNL TLGITSHRAG
VFNALKHFSI PKDGRLTNKP FAIHLTHTPE ECATKCVTVG TKCVSFDYAY FTESCELQHV
IEGPNAKLRI SGSYKNYERL GLQYNSFERY EDIPLEHGKV YFINARIGNI LGYVGYLHSV
GTMVDFTPPM TGALGTDFRE TFKADGCKAS TAQRCAEVTW KKNHRHVIDG KEASTVINGH
NPLDGKYFNT IQCLNSVVFG GSLVTTVCHS LPLIVDTTPP FLHGIEQIYY DEYFDILAIY
YKAGDNESML ADVEFGLGKT KYDVLVMKKS YHQPMNGEDH PFIVIEGLGL KEGVPAWPRI
RVNNGVGLFK ADSGSKPFII DRSPPIVGFV IDGKIHFRDI TYQSSNKEIC VQWTGFHDPE
SGIDHVRWGI GTDPGADNVM VFRTFSHNTI SACVSTVLKH NTKYYSTLIV FNAALNSKHS
KSSSNGVLVD TTPPIPGYAV DGSNLKKDLV FSSEISTKIV SWNNFTDPES GIDNYVVSIY
INNARVKTFN PTNHTHLTDN SVSMQHGDTV HFRIESFNKA GLAVAVKTDG FTVDHTPPNL
VFIEDNNLRL SYQIDDSSLT LRWQYQDKES GIKEYRYSVF ELMHGIKKRV WPKTSMYISI
PPSLTSQPTE IYYTEKLVSG ATYSVHVTAI NQAQLSTAHE SNGVTIDPTP PIMLKVYLGL
SDEDEEIEDG FVQYANSKSL RVSWVGEDPQ SNIKKFFVAI GTRQGDTSVT NGTFSYVYSG
DCPVIRSEWC VEDLTGNIVL NFTEIQWNDH FFYNDELDLK NNFCYFVIEI NSKKVINGTV
CFGQKMHTEK FTDG
//
