ID K1R7T0_CRAGI Unreviewed; 834 AA.
AC K1R7T0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=GMP synthase (glutamine-hydrolyzing) {ECO:0000256|ARBA:ARBA00012746};
DE EC=6.3.5.2 {ECO:0000256|ARBA:ARBA00012746};
DE AltName: Full=Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00031356};
GN ORFNames=CGI_10025128 {ECO:0000313|EMBL:EKC39669.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC39669.1};
RN [1] {ECO:0000313|EMBL:EKC39669.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC39669.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00005153}.
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DR EMBL; JH816450; EKC39669.1; -; Genomic_DNA.
DR AlphaFoldDB; K1R7T0; -.
DR HOGENOM; CLU_014340_0_2_1; -.
DR InParanoid; K1R7T0; -.
DR OMA; HIVHRHP; -.
DR UniPathway; UPA00189; UER00296.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003921; F:GMP synthase activity; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01742; GATase1_GMP_Synthase; 1.
DR CDD; cd01997; GMP_synthase_C; 1.
DR Gene3D; 3.30.300.10; -; 2.
DR Gene3D; 3.40.50.880; -; 2.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR001674; GMP_synth_C.
DR InterPro; IPR004739; GMP_synth_GATase.
DR InterPro; IPR025777; GMPS_ATP_PPase_dom.
DR InterPro; IPR022310; NAD/GMP_synthase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11922:SF2; GMP SYNTHASE [GLUTAMINE-HYDROLYZING]; 1.
DR PANTHER; PTHR11922; GMP SYNTHASE-RELATED; 1.
DR Pfam; PF00117; GATase; 2.
DR Pfam; PF02540; NAD_synthase; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF54810; GMP synthetase C-terminal dimerisation domain; 2.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
DR PROSITE; PS51553; GMPS_ATP_PPASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00886};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW GMP biosynthesis {ECO:0000256|ARBA:ARBA00022749, ECO:0000256|PROSITE-
KW ProRule:PRU00886}; Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00886};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, ECO:0000256|PROSITE-
KW ProRule:PRU00886}.
FT ACT_SITE 96
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 148
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT BINDING 200..206
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00886"
SQ SEQUENCE 834 AA; 92375 MW; 696315A1DB322C64 CRC64;
MNGTDNGGFI NGSGDNRERV AILDAGAQYG KVIDRRVREL FVESQILPLD TPAFTLKEEG
YRAIIISGGP NSVYAENAPR YDPEIFVCGL PVLGICYGMQ KEQNVLLTHG DSIDTVANGF
TAIAHSGKII AGIANEEKKL FGLQFHPEVD LTDQGKEMMS HFLFDVAKCK GTFTMQGREA
ECLKYITEVT GNHKVLMLLS GGVDSTVCAA LLHKALTKEQ VIAVHIDNGF MRKNESQNVV
QSLNKIGLNV KVVKAAHTFY NGSTSISVKT GDSTPRKRKT ERLNTVVCPE EKRKIIGDTF
MRVANEVLEE LNLKPEDVYL GQGTLRPDLI ESASELASGK ADAIKTHHND TELVRELRRQ
GRVVEPLKDF HKDEVRTIGK DLGLPPELVH RHPFPGPGLA IRVICAEEAY MCKDFAETSI
LLKFLMDFSN SVKTPHTLIT RLKNSTSEEE QQQLKRISEE AQLFSTLLPI KTVGVQGDCR
TYSYVVGISS DSEPNWENLM ILAKLIPRIC HNINRVVYIF GGSVRFPVED ITPTYLTNGV
LSTLRQADYL ATEVLHATNT TSSLSQMPVI IIPVHFDRDP VKNSPSCQRS IVIRTFITND
FMTGIAATPN KQFPAQDADA SCRACLTETC IAQSEPMTEP HRIWAARDDT VQPITDVGPK
YSRAGLESHA YEEYDDYYGD DFYYQEYPEP EEPTLISSQK LSGTSNCKKN YKEAQASGES
KGPLTEGSCP IASCQTPKSE SEAATLCPFL LSVNKKSLQT DGFLNAIVSE VESGFPKLEK
ILHHHYLSSD EADVTISGKE GKHSYKLKNF SKLSSEQIGR AVGRYIFNKA KPKQ
//
