ID K1R877_CRAGI Unreviewed; 1372 AA.
AC K1R877;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN ORFNames=CGI_10004768 {ECO:0000313|EMBL:EKC30171.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC30171.1};
RN [1] {ECO:0000313|EMBL:EKC30171.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC30171.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; JH818178; EKC30171.1; -; Genomic_DNA.
DR HOGENOM; CLU_256222_0_0_1; -.
DR InParanoid; K1R877; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.20.80.60; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:EKC30171.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 1372 AA; 154081 MW; 2409EF4A43501534 CRC64;
MNRDVELQKL VKVTVVTIDG NENQVTVPVV GDEQISVTDI YAKACDCLGL QKTSSKWFSL
FCGGETIRRL KPDTFTHSSA KEVSLRKWCF NGRIEANMIK DDPVACHLVY LEAKAAIEKG
LLSVTNEQRE KLEEYEDPAF KLEKDYILLA QTLEGYFSVL IQNCIITDQE PIESTLQVVN
PSESFFYSSM ISTNEEGSTS YENVLYRGPC DGVDDEGRYN GNSIWRLDEQ LNVTLFANLS
FIPRGMAVHP RTNELYVCGV ERDGSRDDLL SLNRRHLIAR FSADGTFISD ITISPHDPHR
LGLMNEDKVC FSDYGKNNKR QLVVMDKMGT VLCVYEGRHE LENPFYPLGT QVDQYENIIV
ADWNNDCVHL LDKNGEFSQF LVDQESDIER PCSLGLDTDG HLWETTTLIS LRQKYVVSTN
HHHSMICVCH GAILASQCWD SFHIYREERN VVAFRPGSAE SRVLSVGRQI ANVTINSTTS
KVNKKPNSVK LMEMKHQNCC AFVGACIDPG RILLLWEYCH KGSLQDVIWN QNIKLDRMFM
FALSQDIAKG LDFVHKSSIH YHGNLKSSNC VVDSRWTCKL ADFGVPSLRH SDKCHKEDEN
PDKLQWTAPE LLRLEKSIDK QKVDIFSLGI ILKEIFTRSG PYTEYPFLRI HELIDKVRYP
VCGAPPFRPK LSVEVQQTPE LHALIDECWN ESVFVRPSAG RILKTLARIN PSKMTMIDNM
IAILEKHANH LEELVAERTS ELDAEKKKTE NLLYRMLPQS VADDLKKGKP IEAEHFDETT
IYFSDIVGFT TICAGSTPIQ VVNLLNSLYT LFDDIITRYD VYKVETIGDA YMLVSGLPKR
NGNRHSKEIA DCAMDIMASI GTFCIPHQPN AKVKIRIGIH SGPAVAGVVG LAMPRYCLFG
DTVNTASRME STGLPLKIHL SSMTRDQLET FGCYHILYRG ETNVKGKGIM KTYFLNGRDG
FTKELPSISE EGMCLKFSPS ATSDLHYMGV ATSPGTPKTS VTAIGEGLNI ERKEMPSVKE
TLQGLSGEDS KKKCASDVMS LTLGDVLPDS VKETVERFRK TGLSCFPQDT NEKGISRRHS
YNDAPKKNCF IPASHDAVPI YEDASYDIRK KLSTGSEAAD SGRGSFRRTG SSSSSLNDVI
TSSLKNITCL DEINVNCLMN RNVKSFPDIM NSTPRENGRL HKRKFSTGDV IDSIQSYRNG
YSAGKLKIRK LSAESFFEGY CISKKTPKQE ETRGRKYSIE SFIRGLLGNK TKLNKSQSTV
KEPCMIKSID KHIKDSHPMH SCSLTENCHE NLAFQDDQNE LHDHDEATVQ EIVNELHEMA
TDPNNMAPGV LPADKLPISL GHIFPRHRVL TKSDSGYGTP ENLSIASATT FL
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