ID K1X6A2_9BACT Unreviewed; 852 AA.
AC K1X6A2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sensory box histidine kinase/response regulator {ECO:0000313|EMBL:EKD25790.1};
DE Flags: Fragment;
GN ORFNames=ACD_79C01506G0001 {ECO:0000313|EMBL:EKD25790.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD25790.1};
RN [1] {ECO:0000313|EMBL:EKD25790.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD25790.1}.
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DR EMBL; AMFJ01035975; EKD25790.1; -; Genomic_DNA.
DR AlphaFoldDB; K1X6A2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.8.500; HAMP domain in histidine kinase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF9; SENSOR HISTIDINE KINASE YRKQ; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EKD25790.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:EKD25790.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..379
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 597..669
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 726..784
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT COILED 367..394
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 852
FT /evidence="ECO:0000313|EMBL:EKD25790.1"
SQ SEQUENCE 852 AA; 98209 MW; 678BD6A62F969932 CRC64;
MRIFNKLILV FLFFISIPVY FVSYTVFNES KNAIEKKLFI KLDIIADHCR KDLEIFLFER
KADLLTLQHC EIYNPNISIL NQFCKDPSNP LYIATKKELD RRLNVYQEAY GYIDIMLTNL
EGRIIYVFNP EHETELGNTL SGKCADLQEV RKQFYVGDIH KTKLKNHPYT FYVGGPVYSD
EEKIIGCVHL EIDLETVNKI VQENQSPEKS LEMVLVKKIP DNKIVFLSSL KYEKDAILNK
IINIGEKYPL PAEKAVSGEN GSGKSIDYRN KEVLAAWRSI PLFGWGLIVK IDSDEAFLPI
NRIKNILIFV AMITVLLATF AAFLIAKSIS NPIHELHKGT EIIGNGNLAY KVGTDAKDEV
GQLSRAFDDM TNNLRQTTTS LENLNKEITE RKQAESYQIL SSEILCVLNE RLALSDAIER
ILVAIKLKTG FDAVGIRLKK DDDFPYFVQS GFSCDFLSTE NTLKSQYNDN RVCCKRENAA
LRFECTCGLV LSGKTDSDNP LFTKEGSFWT NNSLELLKLS EEDDLRLYPR NRCIHENFLS
IALIPIRTNQ EIVGLLQLND RRKDCFNLKM IKFFEGISAS IGVALRRKLA EDELREREQR
LRFHVENSPM AIIEWDMNFI VTRWAGESKK IFGWSAEETV GKPIMDLKMI YEEDVPAVQK
VMEKLSSGKT IQVFSSNRNY NKKQQVIYCE WYNTVLLDPQ GNMLSVMSQV LNITERKQLE
ESLHSSEERY RTIIEASMNG FWFTNLQGRL LSVNAAYSRM SGYSEQELLN MNISELEAFE
KPEETAAHMK ELITKGEERF ESRHRRKDGS YFDVEINAQY RNTEGGRFEV FITDITERKK
MEEVQTFMLQ CG
//
