ID   K1XG23_9BACT            Unreviewed;       462 AA.
AC   K1XG23;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Radical SAM protein {ECO:0000313|EMBL:EKD29150.1};
GN   ORFNames=ACD_79C00039G0003 {ECO:0000313|EMBL:EKD29150.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD29150.1};
RN   [1] {ECO:0000313|EMBL:EKD29150.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23019650; DOI=10.1126/science.1224041;
RA   Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA   VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA   Long P.E., Banfield J.F.;
RT   "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT   bacterial phyla.";
RL   Science 337:1661-1665(2012).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKD29150.1}.
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DR   EMBL; AMFJ01034508; EKD29150.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1XG23; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR034466; Methyltransferase_Class_B.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR   PANTHER; PTHR43409:SF16; RADICAL SAM DOMAIN PROTEIN; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00022485};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT   DOMAIN          190..426
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   462 AA;  54288 MW;  3C6BE9A70C808AA1 CRC64;
     MNKTKKVLLL NPPGNKKFLR DCYCSHISKG SYYWPPYDLL AISGILSDSH NLFAIDCIAQ
     NIKNNECIEI IQRINPDNII FLTGVVSRKY DELFIKEIKI TFPNVKIALT GDFLLEEKEL
     YFKCNDYIDA IFLDFTCPEI LDYINDNLNK SICNLLIRDK EIDLNYNDNF QFSIGLPRHD
     LFNFKYHSLP HMRRYPLATI MTALGCPFAC YFCQQENVKY KMRELKEVFA ELDYFHTHNY
     KEIWFKDLSF GTNEKHYNEI CNYLIEKKYN FSWSCEIRAD TISENKLELM RKAGCHSVFI
     GVETPNEKVL ASFNKKIPLI TTINAFDLCK KYGIKTIAHF IIGLPGETEQ TIKELIDFAI
     KLDPHYCAFN IATPAPNSTF KKLSMKNNWI DSKIDTYDNS ISFPILNTET LKAEKLWKLK
     KDADKKFYFR VGYIFKQLKE INSVYEISNK LKNLYNYFCH HF
//