ID K2AH54_9BACT Unreviewed; 671 AA.
AC K2AH54;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ACD_63C00228G0003 {ECO:0000313|EMBL:EKD49204.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD49204.1};
RN [1] {ECO:0000313|EMBL:EKD49204.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD49204.1}.
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DR EMBL; AMFJ01026726; EKD49204.1; -; Genomic_DNA.
DR AlphaFoldDB; K2AH54; -.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13185; GAF_2; 2.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 452..671
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 411..445
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 671 AA; 75172 MW; 5C47C2097230F73D CRC64;
MFSNLLYSKK EDTDTSEKLR SRLTVLENQN RHFKLIQQLT SSMLSTHSLD SVAQKIVDST
NKEFGYQGAI LYLVREGKRA IFSCAVSNTL SVRLAKKFLS KPLREYTASL DDKNNETVKV
INTGRMIIGS DYPRFISPPV SKFAAKMSVL INRIKTIVAL PIKVQGKTVG AIEYILKISQ
EKVPQADIEM MKIYADQIGI AIENARLYSK VISFNTELKQ KVADATVELQ NQYNDLQALS
KISQTITSTL DLQRISQEIV NSVSTRLKFR AGLLAVISPD KKKLMPIAVS QTESVSKSLK
LLHGDFRKLS VDLTNENNLY VQTAKRLKAT TSDNLKDFFS PPLNSRIAQK IQKLNQIQGT
VAMPLQSKGE VLGILSFSFD KPVSKIDDRE KQVMMTLANQ AGLAVNNALL FDRLKKFSEE
LQERVKQATS ELTIANKNLR RLDKTKSEFI SIASHQLRTP LSAIKGYISM MADGDYGDVS
DKIKSILKKV YNSNERLVNL VNNLLNVSRI EGGRVEFNPV PLQIETSIEN AIAELKKQAD
EKKLALIFER SRKELPKVNA DERLLHQVIV NLIDNAIKYT QKGKVEIFAK LKGKNIQVDM
KDTGVGFEKN EGERLFKKFV RGKDVYKMHT GGSGLGLFIV KKLLEMHGGA VNAQSKGKNQ
GSTFTFTLPA K
//
