ID K2AZ89_9BACT Unreviewed; 460 AA.
AC K2AZ89;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cytosol aminopeptidase domain-containing protein {ECO:0000259|PROSITE:PS00631};
GN ORFNames=ACD_60C00029G0011 {ECO:0000313|EMBL:EKD54984.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD54984.1};
RN [1] {ECO:0000313|EMBL:EKD54984.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- SIMILARITY: Belongs to the peptidase M17 family.
CC {ECO:0000256|ARBA:ARBA00009528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD54984.1}.
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DR EMBL; AMFJ01025354; EKD54984.1; -; Genomic_DNA.
DR AlphaFoldDB; K2AZ89; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00433; Peptidase_M17; 1.
DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011356; Leucine_aapep/pepB.
DR InterPro; IPR043472; Macro_dom-like.
DR InterPro; IPR000819; Peptidase_M17_C.
DR InterPro; IPR048816; Peptidase_M17_N_1.
DR PANTHER; PTHR11963:SF53; AMINOPEPTIDASE; 1.
DR PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF00883; Peptidase_M17; 1.
DR Pfam; PF21337; Peptidase_M17_N_1; 1.
DR PRINTS; PR00481; LAMNOPPTDASE.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00631; CYTOSOL_AP; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 303..310
FT /note="Cytosol aminopeptidase"
FT /evidence="ECO:0000259|PROSITE:PS00631"
SQ SEQUENCE 460 AA; 50422 MW; 755E565B0A629CC0 CRC64;
MLKCFTTNTQ KAIPIKVITP IDFPAWLKKQ NAMTKNWLTS SGFQLTAGKF SLLPDAAGNI
TQVLFGTDDI KNFWSIGNLP VILPEGKYIF DIPEEYYAHY GIAFGLGAYQ FTRYKKPLKG
SAELVLLKND DFSFIENTVE SIYWVRDLIN TPTDDMGPTE FASAAVSFAK QYGASIKQIV
GDDLLKKNFP CIHTVGRASD DEPRLLDLRW GNPKHPKVTL VGKGVCFDTG GLDIKPSSSM
LLMKKDMAGA AHVLGLARMV IEATLPISLR VLIPVVENAI SGNAFRPGDI ITSRKGITIE
IGNTDAEGRL VLADALTEAV SEKPDLVIDI STLTGAARVA VGTDISLMFS NQDDLALNVI
RHGDQQQDPI CRLPLFAGYR EALNSSIADI NNAAMDSYAG AITAALFLKE FVPNDIPWLH
FDIMAWNLKS KPGHPQGGEA MGLRALFSYL RERYSRQNGC
//
