ID K2EZS3_9BACT Unreviewed; 469 AA.
AC K2EZS3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:EKE11099.1};
DE EC=2.7.6.5 {ECO:0000313|EMBL:EKE11099.1};
GN Name=relA {ECO:0000313|EMBL:EKE11099.1};
GN ORFNames=ACD_15C00138G0022 {ECO:0000313|EMBL:EKE11099.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKE11099.1};
RN [1] {ECO:0000313|EMBL:EKE11099.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE11099.1}.
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DR EMBL; AMFJ01005795; EKE11099.1; -; Genomic_DNA.
DR AlphaFoldDB; K2EZS3; -.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EKE11099.1};
KW Transferase {ECO:0000313|EMBL:EKE11099.1}.
FT DOMAIN 224..337
FT /note="RelA/SpoT"
FT /evidence="ECO:0000259|SMART:SM00954"
SQ SEQUENCE 469 AA; 55157 MW; 075341BB8FE4635E CRC64;
MVSNKNIAQN KFKNRTEKTL DSSQRFLNTL KRKKANGYTQ NGVLLMKTLK EITNDPSLLS
ICLFYDVLNY PEGKKILKNS NLSKSEQIII KKLHSLENLS IDSNIKDINK ALRYFSADYR
ILILRITHRL LDIRNLEKFS QKKAKKIAQE TLHMYVPLAS RLGLHKWRHE MEDICFKYLF
PRIAKKLERK FDFYRENDIS CLKHTEKYIK QKLTESGIKC TLENRIKSIY STYRKMIVKN
RKFDELTDRL AIRIIVAKKD TCYRALGVIH SIMHPIPGKF KDYIGTPKEN GYQSIHTVVF
PLPNVTNMPI EIQIRSKEMH KECEFGVASH FHYKKDSYTM RYNKKTRADL IKNLEIIKHE
SPTSTQKLSH LMQSYFRGDQ VLVFDSKNRV YHLTKPASAL DFVCIHYKKK IAYLKSVKIN
GILGSLETLL QDGDVVEAQF QEKKSFSKRW IKMCHREQSK KMLLEISNE
//
