ID K2MP46_TRYCR Unreviewed; 3450 AA.
AC K2MP46;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dispersed gene family protein 1 (DGF-1), putative {ECO:0000313|EMBL:EKF27424.1};
GN ORFNames=MOQ_008853 {ECO:0000313|EMBL:EKF27424.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF27424.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF27424.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF27424.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF27424.1}.
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DR EMBL; AHKC01018264; EKF27424.1; -; Genomic_DNA.
DR EnsemblProtists; EKF27424; EKF27424; MOQ_008853.
DR OrthoDB; 131534at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR021053; Dispersed_gene_fam_prot1_C.
DR InterPro; IPR021004; Dispersed_gene_fam_prot1_dom4.
DR InterPro; IPR021282; Dispersed_gene_fam_prot1_dom5.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF11024; DGF-1_4; 1.
DR Pfam; PF11038; DGF-1_5; 1.
DR Pfam; PF11040; DGF-1_C; 1.
DR SMART; SM00710; PbH1; 12.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3049..3075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3120..3137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3157..3182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3188..3209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3259..3280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3286..3305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3312..3334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3346..3371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2833..2907
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11024"
FT DOMAIN 2920..3197
FT /note="Dispersed gene family protein 1"
FT /evidence="ECO:0000259|Pfam:PF11038"
FT DOMAIN 3369..3444
FT /note="Dispersed gene family protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11040"
FT REGION 3391..3425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3450 AA; 359929 MW; FEE0B18AD1B7F800 CRC64;
MWSAVGACPR NRHRVLCRTI AAVRVVLLVV LALLVAAAAW MPAVHAVVLR LRGGRVDRAI
TVGRAVDTVL MDGVHITNGV AVVFDVPAML PGALRIGLRN CVCDGGAQIY VRGYSGEPAS
DRSLEVSVSG LSGSYCSLVF VHNLPAHTNV TVRDSTIVTA GPMHYSQLSG LTDAVASPLV
LYATSLFQTQ LRVGNTVLRS LQAGGSAVYV GGDVDLLSSA VVLDGVLLEA SGGPSASAMH
VASSSRLSLR SRSVISVTNV SVVSSGGGFV LGERLAVSDS VLRFVSVEGS VASSLVRCDG
GTVGGGGWLD LRDVWAVGEA SSVASLSGVT LGGGAVSIAR CAATGATLVS GLTIAGGVVS
VQCNRAGGRV LQSSGDYRSA GLSSVSVVPC DGCAAALACF DALTATFSEC ACSCRAGGVG
EACLPFDVPV ARAGGGGGGA QGCVSGVTLT ESVTVGGVRA MACFDSVVFS GPITVAVDLR
SMDAFADALN VTLRHCVLAG GAQLRIGGLS ESTARPMPHA LVNMTNVTSL EGTIVLHGAM
PQRSSLLLAN SMLRATVGGS QYVPTTPGHA GFRCAPALVL DGVRLLSTRF VMTRSTLVCG
GGSCAIILVE RSLGVNLSSA FYMDNCAVKS QTHVMYAIES DLRVVGGSVF SIQNSLWSVP
SAEYHKGVCV FGDVAVDGGS VLQIVSSSFR LGFAMLITNT LSVTGGSWLV HRNNEFHTAY
VVYVVGENGV AFRDQSVWSI LDNKLTHGSF SSYDAHMIND WSPPSDSRPT IYGVCNELRG
SPVTDYREDL NIGTPVKVLD CGACTVDAVC FAARTSSISG CECVCTAGGY GDTCLPAAVP
DGLGPLPLPE SKDTEVRCVH GGSISSVDDP DPGVRGLCFV NVTFTAAIVL DLSRFAAPQQ
TLNITLLQCV LVGLSIKGSG QSVHVSVTSS MLDSGALEFK GDFGASSQIL LAGSLFVTMS
SYAILFLKFF LRANSSLLLL DNCIEGNSHA VYFSIAAVVD GGGIIVKGNT LGTKRDDEGV
ESSVYVHGVD VMNGGYFDVE NSTMSAVHGI YLFGVTTLSS AGLLRVADCN FFESTKGFVS
ALLYFEGSLI LESGAQWRVE GNSVSAASVF TLPDLQHKIQ LSDSGTTVVL AHNRQVERSA
DFANFFSSSI VVKPPARFVV GCNMHNDEEV SYDGVFPEEV EIFMCGTCND DAACYMPGTE
SVARGSCSCS CKDGWHGASC LPFEVPDTFL LPVAERIVDG DTSCVVNQTL KNITLNMWKT
HHCYVGVTFS GVGAALTFFL NRMPLHFPIN ITLTGCTFRE GSALQFVGGA EASDSAGVLI
RVSQTVMRSS VVAFLLALPQ RCDIAVTEVD AVQVSEVQLP RSTINILCVV VLQNVFLNAS
SLLVSNVKAR ALRPDGVGFY STGTLTLEHG SSLYLRYCSF EGYMHLLYVH RPSMNGQSVF
ALLNNTISSG ISLFFQHRGF SVSDHSVLRV VGNSGSVSYA ILADGFWIVQ GSSWLDWRDN
DVGVGAMFHE AESTSFTIDD SSVVTLTGCK MGWTGLSKPL LSQADAGYRF VAGCLMVAGR
VLTTATELEL HGVTKVTTVA ACGDCTEYGD CFAPLATAVI DCRCQCAAGG HGDVCVPTPV
PAGPPPPLLP SPPPPPPVGE CISDMVYPEV VQSVGGGLSW LCYRNVTFSG SGMSLTVLVG
AMTGDVANVT FDRCTWRDGA VLLLLGNAYA AVGSLNIVVT GNTFYDALLS PEGVFPPHTN
ITISGNRFTV TRRIPRSGLG LDSPSCVAMN VLAIANDSAV VLSDNVFQSV TASLGAIHLV
LSALRVSWHS LFAVVGNTFH MDGGNGTLIY LQGSRYFSSL RVVNNSAVVI RGNVVSRPVK
CFILFIRALG VESHSAFVFQ GNEMQGSLVV FLSSYFSYIY YNSWLQLSGN LCRESSSDAF
AFFYPTVNLR DSTVSVSGNQ FMSSTDTPTV LRIHTESSDL SNGALVAACN TVNGEEGVEY
SIPSMYNPTI LTCRDPCAIS TSCFPAYTTT ASSDGCACTC AEGGHGDACL PVAVPEPPST
DGAELCVRDV RVDLEVNVGL GTSLACYVGV TFAADVVVDV ASMSGSVRNV TLANCTFLSG
ASLYVVGWRS DPPAGERADV LISRLESRSG GGVVVANRFP PGSRVTVVDS VLIAEKRVAY
RDAYGLGDAS ACLVLRNVNL KGSVLIIART HVAAVFRDAV GVLVAGGVAL SARGALYVDG
LSVQTALGLC VSVEGDFAAS GDSVVAFFDS DFLLCKHAVS VRRAVSVSGS AVALVRSEFS
STGDYAVAFY STVSLASGSM LLAKDNVHDG VLREMLYAAG AVTAVGSTLS FVRNRALLPR
MLSLSLSLAA GAHLRVACND AGGRVLSTAE EYAAAGFGDA ASIEVVGCDA CDRDTHCYAP
GTASASMRNG VCVCVCGSGG YGEACVPVGA SALPPAVGTA SSVFSREGVT VESVFVVPAG
ASEVTLRHVV LDGVSPVLYV PWMAREGVRI VVQNVSLQNG AVLYVMGGGA LRGAGAAESD
KSGPVELSVC GVEALNGVLV LSGRFPAGSV LTVTDSLLVA ARPTPLVYLP GSRSSPYAPV
LVLSDLRLVR SVLVVSDVAL VTVMTGGRTV VLDGAVLELV GGGVALDAAV LGGDYALYAS
ARVVASGGAV LRVSGSQVYA AHGLVFDSGV EANASAVVVN DNTGVLTDGA LLVLRGSASF
ASGSWLSVRG NSISGRLLSV PSYPRSADFV QSTLTLHGNA GSGPVVMDGT VALVGAGGRF
VVGCLTLNEQ ALQPMDYRSA GIIGKFRPVM CGVCGADVSC FAAATRAMSG SCRCRCAEGG
YGRDCLPVYL PRVDGCNRTP VLPLLSHTAT LTETHSPTPK WTPSLSTTHY SPTQYGPTET
LQVTETAALS STRTPTASVS STLWWSDVAC PTLAVTTTAA GGSLTQNDIR GGGSAVPTRL
MVALPPPFRW TSDPQLGTHP SFVPVSTVQP RGFGGPWGAM LRNATWVRNA TNPFTVLELD
VPVHRGYFIA ADETIVIRCD AVAVFGGCKG VLLGSFTIIP NTLPAAATAL SAITGVVAGA
TAVAVVVTGG LGSILEMQAL GVFARMPCAE AHERASTVAL PYFLSVFAAL DPLWMVVGNA
LLAAVFGCVH YGVTTAFQRW RGVDAASAWA AMRFPSLTYV VAHAMHLGIF FGSVLALAMP
GARVQHRVIG VVGVLYGVAF PAGVCYLIAR HTGACFTRYW QFSRKPLHER LLYPVGYWYP
VVQQRMYGSM LTNMSGSHVY WCVFQLSVLC VVGLIAAVRP PVGGCHVQYF SMAAVLLAGA
GVVAFTNMMR SAFLTVMHAA SFVLLAALCV VSAVNHLAPS DGGARAYVAI VLLLTTVLLA
VTVYCVLVWY LEDRHWQELR EPRRGGLEAL LRDDDDGEEE TQMSHDVTPS SYRPPAPPRH
MAGDTHSDAL SLFDRASSAS CSINYAPLDR
//
