ID K2MYP1_TRYCR Unreviewed; 695 AA.
AC K2MYP1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF32185.1};
GN ORFNames=MOQ_003970 {ECO:0000313|EMBL:EKF32185.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF32185.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF32185.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF32185.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF32185.1}.
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DR EMBL; AHKC01010201; EKF32185.1; -; Genomic_DNA.
DR AlphaFoldDB; K2MYP1; -.
DR EnsemblProtists; EKF32185; EKF32185; MOQ_003970.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..695
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003864892"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..508
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 66..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 76026 MW; B9E9C12D44E6CDDB CRC64;
MGGRVCCFNI FLSISISLTH ALERRKTNAI IATVKFEGSE RTNSTHAPAT HTYICMHSRV
AAVKVPRTHN RRRVTGSSGR RREGGESERQ RPNMSRHHFY SAVLLLLVVT MCCSIGASAG
EVSAPVSSKS KPFVWRDKKN EETVSSLRVP SLVEMNGKVF AVAEAQCKNS SDKLFTGIAS
KLLALTDRAS EEELVATQVK TQILVECPSN VDECASKDAH VEGSQSEKKV DVSRPTAVVE
GGKIYMLVGN YSQTAVAQES GAEDSGILLV KGDVSQESGT ENKIEWENTN DVSRASLGAE
LKSWTWLTGG GGLGVDMGDG KLLFPVEGTK KIKKDAEPEK NEKAVSLIIY TLSDSASWTL
SKGMSADGCS DPSVVEWEKD KLMMMTACDD GRRRVYEIRD GGESWTEALG TLSRVWVNPT
ENEKSFRSGF TTATFGEEND QKNVMLITLP VYAKKDNPKD KLHLWLTDNT HIVDIGPVSG
EDKEEIAASS LLYKSDDNNK DELIALYENK KDGEETSLSM FSVRLTAELQ RVKDVLNTWK
EVDKRVSQLC LSESDEKDRP TVTPCSSTFN ITDGLVGFLS GKFSETTWRD EYLGVNATIN
KGTEEATAAV TAATGPPDGV TFRGAWAEWP VGAQGENQLY HFANYNFTLV ATVSIDGVPE
GSIPLMGVKM NGDENKVLLG LSYNKKKISG RYCAM
//
