ID   K2NH02_TRYCR            Unreviewed;       942 AA.
AC   K2NH02;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EKF38615.1};
GN   ORFNames=MOQ_001174 {ECO:0000313|EMBL:EKF38615.1};
OS   Trypanosoma cruzi marinkellei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF38615.1, ECO:0000313|Proteomes:UP000007350};
RN   [1] {ECO:0000313|EMBL:EKF38615.1, ECO:0000313|Proteomes:UP000007350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B7 {ECO:0000313|EMBL:EKF38615.1,
RC   ECO:0000313|Proteomes:UP000007350};
RX   PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA   Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA   Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA   Andersson B.;
RT   "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT   with the bat-restricted subspecies T. cruzi marinkellei.";
RL   BMC Genomics 13:531-531(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKF38615.1}.
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DR   EMBL; AHKC01005297; EKF38615.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2NH02; -.
DR   EnsemblProtists; EKF38615; EKF38615; MOQ_001174.
DR   OrthoDB; 139855at2759; -.
DR   Proteomes; UP000007350; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   InterPro; IPR021287; Trans-sialidase_CS.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   Pfam; PF11052; Tr-sialidase_C; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        42..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..441
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..892
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..804
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..850
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   942 AA;  100299 MW;  740E787DB9AB4B27 CRC64;
     MLSRVAAVKA PRTHNRRRVA GSSGRREGRE SEPQGCHMTR HLFYSAVLLI LVVMMMSCGI
     CGAEKPAMQS TGPQFEWKDV NCKGDSVTVE ILGVPGLLRV GNDVFAVAEA QCKGGANIFT
     GIASQRLTKG NANTPVEVLK EVEKIKALEK HGSSEAEKIN VSRPTTVVEG SDIYMLVGKN
     SPTAAGSEQN SGADGWEFFL VKLDGIGKGD ISQESQWKNT NDVSLASFDE QHQSWTRLIS
     GGGSGANLKD GTLVFPVEGR KKESESGKTV SLIVSFLKNT KSWTLSKWMS ADGCSAPSVV
     EWKDNQLMMM TACDDGRRRV YESGDKGESW TEALGTLSRV WGNKQDGSGV RSGFTAAKIG
     NGVEDDKRNV MLVTLPVYSK EKDSENKEKE KSELHLWLTD NTHIVDIGPV SGKDDDVAAS
     SLLYKSAGSE TINDELIALY EKKGSEEPQS PGMVSVRLTE RLERVKDVLA TWKKVDDIVS
     KLCPTPIVAQ GSPTTNDCSA ANITNGLVGF LSGNFSETTW RDEYLGVNAT VKKGKKEGVA
     EAVRVAAGPS DGVKFHGAWA EWPVGAQGEN QLYQFANYNF TLVATVSIDG DPKEGSPVHL
     MGVKMNGDEK TVLLGLSYNQ KENKWTLLCG GKPNSEKPSS KREAEKTYQV VILLRNGTQG
     TAYVDGQRVG DPQCALQDMD PKGISHFFIG GGGGSAGSQE GVPVTVTNVL LYNRPLSSEE
     ITALTKRLSI QKQKDLQTET GVIRAPEVSA LAAPEAVPVS DRDGQHLTAQ ELLKRGEDPG
     SGGASKSTST TVTTPSSGSQ SAERLASGGF RDGNKNVNAA SPSNDNPLVR TGGGDTVQGN
     GAQQPSVGAL DTADTKLPNA EGEGQDGLAV NSEASYGEKD ETPGGTGGRE EKQIRDVNAT
     ALSSNLGNLS QANNTDAGTM RESGMMLPPL LLLLGLWGFA AL
//