ID   K2NJN2_TRYCR            Unreviewed;      1312 AA.
AC   K2NJN2;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   13-SEP-2023, entry version 36.
DE   SubName: Full=Tubulin folding cofactor D, putative {ECO:0000313|EMBL:EKF39600.1};
GN   ORFNames=MOQ_000164 {ECO:0000313|EMBL:EKF39600.1};
OS   Trypanosoma cruzi marinkellei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF39600.1, ECO:0000313|Proteomes:UP000007350};
RN   [1] {ECO:0000313|EMBL:EKF39600.1, ECO:0000313|Proteomes:UP000007350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B7 {ECO:0000313|EMBL:EKF39600.1,
RC   ECO:0000313|Proteomes:UP000007350};
RX   PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA   Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA   Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA   Andersson B.;
RT   "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT   with the bat-restricted subspecies T. cruzi marinkellei.";
RL   BMC Genomics 13:531-531(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKF39600.1}.
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DR   EMBL; AHKC01000687; EKF39600.1; -; Genomic_DNA.
DR   EnsemblProtists; EKF39600; EKF39600; MOQ_000164.
DR   OrthoDB; 5477080at2759; -.
DR   Proteomes; UP000007350; Unassembled WGS sequence.
DR   GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR   GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR033162; TBCD.
DR   InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR   PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR   PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR   Pfam; PF12612; TFCD_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT   DOMAIN          1002..1172
FT                   /note="Tubulin-specific chaperone D C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12612"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1312 AA;  145070 MW;  7EF8BA711EE98BC6 CRC64;
     MKKEHEEMDP VATAAMLPEA NEVDGTSPAE GAEGENDDDW GPAFFEEEDE CVSLLARLQE
     SLQLQDDRDA TLPTVAEDPT GVAAALYRLD RIIARYQESP HLLHGYLEVL LGPLVATLQS
     LLPAATDIWR MEDGIEKPEC DTAVSAQEEP DYTLGANYDE YDLDAAKTAI HHVSRAIYVI
     VKTAGEKCCT SYFSNDVKLC EDVFYALRLW QRSAKYRREW EVRYCLLLWL SNLVLVPFSL
     TIIDSTDRGG SLSDAVLETA MAFLSDTSKC REGAALLVAR LLTRPDGEAH RRRFFAYARE
     VITDTSKSSF PLHGVLLALA KTLKCGQRRE MAPYAPGLIP IVAGVLESRS SDALVCKAAV
     KVEQRLALVL LRGRSAPWKY QRHVTSLDKN LAASMPSDVA ADVNFSIGAH RTVENGNYNN
     NSNTNSNSNG NGKMDVENED DECVVENDEG LEEAIGLMLV NLSHKDTVVR WSAAKGIGRI
     CERLPRVMAE DVIAAVLDVF TNENSDSSWH GGLLAVAELC RRSILHPQHL PTMLPRIIQG
     LAFDLIKGTY SVGSHVRDAA CYACWSIARA YDASDIEEHV HKLSTSLVVT SLFDREVHVR
     RAAAAAFQEC VGRLGNFPDG IRLVTTMDFF SLASLQNAYL HVAPLVAENA SYRERMLEEL
     VANKLLHWDR RVRCCAARAL GLLATSEVNT AVREIVPELL RRVTENSVAT RHGAILGIAE
     MIEALDVSVW PEDVLSQFAS LTPRVDAARL FRSRGGEYVR QACCRLLAAL AHRRLSLPET
     IEVQKVGGAV ARAKTLGKLQ EFFEDTWKQI LEWLQFDAVD AYESFAATYY TEFIAPFHQK
     VLEKMLDGSG EEHNPMERRG NLLAMGALPW SIICAVPPST RAEEEEGEGE GQSAYFLMLL
     HAAMEGTRPE RRKELQDAES RRNAVRSLGK ILLRIPPGSL QLTSELYECA VQCILNALDD
     YAADRRGDVG SFVRLEAIDA LPAVVQYGMQ CGLCSPLLTL RAAQALLKQS MEKLDRLRGR
     AVLSLSKIVH FLDNIADKEK ASAISVLCNV LRENKTAEWS LPQVAFMTLA CPLLQTDLFA
     PCVVEGLAVS AGSLSLHIMQ PAVNAFLHGF RVSAENRVFL SHVLIEVAAK YAHNERVVVP
     LCVTINRLMT VGVFDESCHM DVVEVLRHEL KHYATSIHVL LPLVGVLGDL CRSSVPEARE
     AAWGLSLVMI ASRYPKVRAK MATDMYTALL VFTSAEASEG CTKAMQHLSA TQWDANDVAK
     VRGARDALYC MLNISPPSKT TECDEAQQQQ QQKKKSRMVA GSYLYLVQEA GY
//