ID K2P3R7_TRYCR Unreviewed; 372 AA.
AC K2P3R7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=Dehydrogenase-like protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=MOQ_002311 {ECO:0000313|EMBL:EKF35847.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF35847.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF35847.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF35847.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF35847.1}.
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DR EMBL; AHKC01008894; EKF35847.1; -; Genomic_DNA.
DR AlphaFoldDB; K2P3R7; -.
DR EnsemblProtists; EKF35847; EKF35847; MOQ_002311.
DR OrthoDB; 129282at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF14; DEHYDROGENASE-LIKE PROTEIN; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 9..180
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 183..239
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 372 AA; 40155 MW; C0E8F06265B2B805 CRC64;
MAAIKRSLNV GVVGMGNMGV PIARNLGFKA RSAMYLQIHS RTLSKARRVC DDLSVDGASC
AMRIHDRYST MTKWCDVLLL ALADVHAARH ALLEGSEALI RNARKGQIIV DHTTVDIETS
RECAYEAEKR GAYFLDAPMS GSPRACFNAQ LVLMVGGHAE SFQKMLPIFH MYADNVHHMG
ASGSGSATKM ITQALVASHN AAAAEALIMA HRLGVEDQKK LVQVLDASWS SSTMLRRNAA
LLQDLIRNPD KAPPTSTASV DRLLEDLALL DASLPKRTGT KNSSENTDVD EPFPVLDTAL
RSLAAASDAG MGDRDIATIV HYVQAGEVEL RNRRAMNFGS TDSVGQRETV SGVAAVEAAE
AEPVEFGKED FY
//
