ID K2QR69_MACPH Unreviewed; 416 AA.
AC K2QR69;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=adenosine kinase {ECO:0000256|ARBA:ARBA00012119};
DE EC=2.7.1.20 {ECO:0000256|ARBA:ARBA00012119};
GN ORFNames=MPH_10513 {ECO:0000313|EMBL:EKG12396.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG12396.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG12396.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG12396.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenosine: step 1/1. {ECO:0000256|ARBA:ARBA00004801}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000256|ARBA:ARBA00010688}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG12396.1}.
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DR EMBL; AHHD01000451; EKG12396.1; -; Genomic_DNA.
DR AlphaFoldDB; K2QR69; -.
DR STRING; 1126212.K2QR69; -.
DR VEuPathDB; FungiDB:MPH_10513; -.
DR eggNOG; KOG2854; Eukaryota.
DR HOGENOM; CLU_045832_0_0_1; -.
DR InParanoid; K2QR69; -.
DR OrthoDB; 22683at2759; -.
DR UniPathway; UPA00588; UER00659.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0004001; F:adenosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd01168; adenosine_kinase; 1.
DR Gene3D; 3.30.1110.10; -; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR001805; Adenokinase.
DR InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR45769; ADENOSINE KINASE; 1.
DR PANTHER; PTHR45769:SF3; ADENOSINE KINASE; 1.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00989; ADENOKINASE.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00584; PFKB_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKG12396.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine salvage {ECO:0000256|ARBA:ARBA00022726};
KW Reference proteome {ECO:0000313|Proteomes:UP000007129};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 92..409
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 416 AA; 45564 MW; 19ED4B539BAD8F42 CRC64;
MASFLCSRTI LPKTTPVLRS TPLIGEARRR FLGSRAAAPL HFSLLRKHPT TRPPPHPNTT
IRHHTMASTG NYELLCLENP LLDIQGVGDE KLLEKYGLKA NDAILAEEKH MGLYEDLLQN
YNAKLIAGGA AQNTARGAQY ILPPNSAVFI GCVGKDKYAE ILKETVKQVG LRVEYRYDEE
HPTGRCGVII TGHDRSMCTD LAAANHYKIE HLKQPEIWSL VENAKVYYVG GYHLTVCVPA
ILALAEEAAK NNKIFALSLS APFIAQFFKD QLAQTAPYWD YVIGNETEAR TWAESNGHDT
KDIPTIAKLM AALPKANKTR PRTVIITQGT DPTVVAVAKE GGDAEIKQFP VHAISKDQIN
DTNGAGDAFA GGFIAGIVQG KDLETSVDMG QWLAKLSIQE LGPSYPFPKQ TYSKSA
//
