ID   K2R448_MACPH            Unreviewed;       617 AA.
AC   K2R448;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   22-FEB-2023, entry version 28.
DE   SubName: Full=HEAT domain-containing protein {ECO:0000313|EMBL:EKG17101.1};
GN   ORFNames=MPH_05673 {ECO:0000313|EMBL:EKG17101.1};
OS   Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC   Macrophomina.
OX   NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG17101.1, ECO:0000313|Proteomes:UP000007129};
RN   [1] {ECO:0000313|EMBL:EKG17101.1, ECO:0000313|Proteomes:UP000007129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MS6 {ECO:0000313|EMBL:EKG17101.1,
RC   ECO:0000313|Proteomes:UP000007129};
RX   PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA   Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA   Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA   Saito J.A., Alam M.;
RT   "Tools to kill: Genome of one of the most destructive plant pathogenic
RT   fungi Macrophomina phaseolina.";
RL   BMC Genomics 13:493-493(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKG17101.1}.
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DR   EMBL; AHHD01000256; EKG17101.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2R448; -.
DR   STRING; 1126212.K2R448; -.
DR   VEuPathDB; FungiDB:MPH_05673; -.
DR   eggNOG; KOG0211; Eukaryota.
DR   HOGENOM; CLU_015533_2_1_1; -.
DR   InParanoid; K2R448; -.
DR   OrthoDB; 759105at2759; -.
DR   Proteomes; UP000007129; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   PANTHER; PTHR10648:SF4; PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED; 1.
DR   PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR   Pfam; PF13646; HEAT_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 10.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007129}.
FT   REPEAT          12..50
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          89..127
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          206..244
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          247..285
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          286..324
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          325..363
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          364..402
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          403..441
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          520..552
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          583..617
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   617 AA;  69004 MW;  6239C51DD6F6E334 CRC64;
     MDAPNQSDEL YPIAVLIDEL KHDDVLLRLN AIRRLSTIAL ALGAERTRDE LIPFLDESVE
     DEDEVLTALS EELGNFVEYV GGPEYGHVLI SPLENLAGIE EPLVREKAVE SLNKVCKELN
     SQQVEEYFVP LTIRLSTADW FTSKISATGL YVEPYPRASA QAQESLRQHF GKLVHDDTPM
     VRRQAANNLA KFVKAGMPPQ TVIEDMIPLF QRLTTDDQDS VRLLTVDVLI AIAEVVPKEE
     QTSHGVLLTA LRHLFEDKSW RVRYMVADRF EKIAKAVEEE LITRDLVPAF VKLVKDTEAE
     VRSAIAGQIP GFCRLLPKET LLQEVMPNIE ELVSDQSQHV RAALGTQISG LAPILGKDET
     ITHLLPMFLQ MLKDEFPDVR LNIISKLEQV NDVIGIELLS QSLLPAIVQL AEDKQWRVRL
     AIIEYVPLLA SQLGVKFFDE KLSSLCMSWL GDTVFSIREA STQNLKKLTE VFGVDWANEA
     IVPKVMAMGA HPNYLYRMTT CFAISTLAPA LSLSVIEASI LPMMEKLVDD RIPNIRFNVA
     KSYEVLINVL KRLPETGTIV ELEKAGSSPA GSQRGLDLIQ NSILPNLEKL QQDDDVDVRY
     FATTAANSFT DAMHTEP
//