ID K3UX21_FUSPC Unreviewed; 1935 AA.
AC K3UX21;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=FPSE_02590 {ECO:0000313|EMBL:EKJ77216.1};
OS Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=1028729 {ECO:0000313|EMBL:EKJ77216.1, ECO:0000313|Proteomes:UP000007978};
RN [1] {ECO:0000313|EMBL:EKJ77216.1, ECO:0000313|Proteomes:UP000007978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS3096 {ECO:0000313|EMBL:EKJ77216.1,
RC ECO:0000313|Proteomes:UP000007978};
RX PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT "Comparative pathogenomics reveals horizontally acquired novel virulence
RT genes in fungi infecting cereal hosts.";
RL PLoS Pathog. 8:E1002952-E1002952(2012).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKJ77216.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFNW01000061; EKJ77216.1; -; Genomic_DNA.
DR RefSeq; XP_009253984.1; XM_009255709.1.
DR EnsemblFungi; EKJ77216; EKJ77216; FPSE_02590.
DR GeneID; 20361209; -.
DR KEGG; fpu:FPSE_02590; -.
DR eggNOG; KOG0902; Eukaryota.
DR HOGENOM; CLU_000893_1_0_1; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000007978; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:EnsemblFungi.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IEA:EnsemblFungi.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:EnsemblFungi.
DR GO; GO:0140504; P:microlipophagy; IEA:EnsemblFungi.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0060237; P:regulation of fungal-type cell wall organization; IEA:EnsemblFungi.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000007978};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1365..1552
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1625..1919
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1935 AA; 216449 MW; 0CC415330E002046 CRC64;
MTGDIRSKAL QKIASLSANS STTAFDRSDL DRLCRACHAG AKSKDYVNGN QNRNSLGRVP
MSIREFEVLI ALCKTAPKIK SSQSAQRLSY QLFPYILEAH VQLFVPSPFF RKIDPSPTEA
LAFHVTGALL ALGINYDDLQ ETVTDKIWSF VNSCRRASES IISPQAGDPE NPHLEDAIRT
VTIAVALLGF LDAAAAQADF WRSGGRLALI KKIREILSEP FLIAVETALS TIRNCHSQDR
EVKEWKRYLR QYASSGRPLG AMLLHKSFAH FVVSSTSLMV KDPASLRQSH VLDIYISQGE
SLRDIASITL EAEFKTVEDY AVLAVEEIQY IEGGADFIRM GSPDQQSLAY AVKAAALISY
LNCALLNEDA ADPEILMNWL QETLDDDVQM ADQTLASVTL RCLALICQIS PSFSSNVSRI
LPRFIVQDAP QKNIVTIASN SLAYALKMLS KDAVIGTLYT LGNVLSPGSD QGFANDQIDG
TASETGLNPI YARRQSIGSS ISVQLYGEEE TAIVSGNVVQ TICGIAAAFQ DEKITALAQS
MLQQKLEKVN TGVDARIISG AAALALEGGQ LEFRSLLKLF SKLCHTGVVD NQLFLLEAVR
NARTFISANL RRDSQLFDIY FEYLLDDIIG LGDVHSSGHT KESDVQMAAK EIAELLHPLA
IFMSSNDFAS NPVTDDETYS LLRDAWFNIV VHGFATNTDR GKQYLRELRM IAIHSPPLVA
EQRGEQVESD IELNTVLRRG MSNDRESLQK KLLSELVPSK ANEIKSLSYR KVIFLQAAYL
MEILRADSGD CTKVLSYFLE PSMAKGDVSS AMEGVAAAVM DKYIQKTQSG MDPTFSAQYA
AEQLASIFCS CCHRIERVQQ AAFVCADRIL RDIPSALCHR SSLFALIELL SLMWSSCLEA
ETDVYAPRST FTSELGGVTV ELSDDYDFRR WTVDILSRKA RVWVNTAINI SPLDVKGILQ
TYLSEFSDEG AYGHVSLGRS FALELGSTVP STDNRLQSMD KIGNSSVNTA SAFVAQYTTR
QEYRYGETLP DRGTELMSFM SHNRRMSFAQ SSVKESASAT TALAHIEARI LSKKSTSTNE
VRDILRRAAA LLCRTDKDEA AVAHHLVSIP FALFTKQSIN LGVSLWLGVI NENPRQESRL
LNEIVQQWEF TLGRKVGLFS PTLHHVDPFF LKEEFAPSEL EALAKKKQIV HDILSPHTRL
LQFFASHYNA TRLGCPDIQR VFLRMLDLTL EAMKQSATHP MAREIRFQLI LFGLRVLKSS
TTLKPAAQWR LKERILTAGL SWFRSAPKWS FGGNLLQMKT EIRLISDVLV ALQLVSSIGA
QTVGNVKSLQ SKEQLLDLML RNEQTRLIVW VNPLNNPSTQ ALTQPAGKAP TEAALLPLIR
TAWWQDPAIA IELATRFPFP RLQRDIRFLL LTMPEKAIFE PEALNLIFGG FLPDDVGPQQ
LKYMLYWEPV NPVTAVTMFL PAYQYHPFII QYAMRALESH SVDVTFFYVP QIVQSLRYDS
LGYVKRYILE TAQFSQLFAH QIIWNMKANS YKDDDAQIPD EIKPTLDTVM TQMVDEFAPE
DRDFYEREFA FFDEVTDISG KLKPFIKKSK PEKKQKIEEE LRKIKVEVGV YLPSNPDGVV
IGIDRKSGKP LQSHAKAPYM ATFRIQKNKG GVSEVDEMMD EKDGGDHGTP ERTIEVWQSA
IFKVGDDCRQ DVLALQMIAA FRGIFHDVGL DVYVFPYRVT ATAPGCGVID VLPNSISRDM
LGREAVNGLY DYFISKYGNE NSLRFQRARS NFVKSMAAYS VISYLLQFKD RHNGNIMIDD
AGHILHIDFG FCFDIAPGGI KFERAPFKLT TEMVAVMGGS MEHQSFKAFE ELCVKAFLAS
RQYCEKLSQI VSLMMDSGLP CFKPESVKHF RERFVLDKSE RDAANFMKHL IKTSYSSHST
GIYDQFQLLT NGIPY
//
