ID K3XEH3_SETIT Unreviewed; 848 AA.
AC K3XEH3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=FAD-binding FR-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=101777050 {ECO:0000313|EnsemblPlants:KQL07615};
GN ORFNames=SETIT_5G372100v2 {ECO:0000313|EMBL:RCV28019.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV28019.1};
RN [1] {ECO:0000313|EMBL:RCV28019.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL07615,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV28019.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV28019.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV28019.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL07615}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL07615};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RBOH (TC 5.B.1.3) family.
CC {ECO:0000256|ARBA:ARBA00007975}.
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DR EMBL; AGNK02003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV28019.1; -; Genomic_DNA.
DR RefSeq; XP_004970493.1; XM_004970436.3.
DR AlphaFoldDB; K3XEH3; -.
DR SMR; K3XEH3; -.
DR EnsemblPlants; KQL07615; KQL07615; SETIT_000290mg.
DR GeneID; 101777050; -.
DR Gramene; KQL07615; KQL07615; SETIT_000290mg.
DR KEGG; sita:101777050; -.
DR eggNOG; KOG0039; Eukaryota.
DR HOGENOM; CLU_005646_6_0_1; -.
DR InParanoid; K3XEH3; -.
DR OMA; CMEVGQY; -.
DR OrthoDB; 367877at2759; -.
DR Proteomes; UP000004995; Chromosome V.
DR ExpressionAtlas; K3XEH3; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016174; F:NAD(P)H oxidase H2O2-forming activity; IBA:GO_Central.
DR GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR013623; NADPH_Ox.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF54; RESPIRATORY BURST OXIDASE HOMOLOG PROTEIN J-RELATED; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR Pfam; PF08414; NADPH_Ox; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SFLD; SFLDG01168; Ferric_reductase_subgroup_(FRE; 1.
DR SFLD; SFLDG01169; NADPH_oxidase_subgroup_(NOX); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxidase {ECO:0000256|ARBA:ARBA00022559};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 298..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..210
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 532..660
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 95935 MW; 6EA97620890D9ADF CRC64;
MAGYGDRRSP PLDGIAVDGG GRAQSPGAGT GRLPPPPGGF ARGLMKQPSR LASGVRQFAS
RVSMKVPEGV AGMRPGRMTR MQSSAQMGLR GLRFLDKTSG GKEGWKAVER RFDEMTKGSG
RLQKESFGKC IGMGDSKEFA GELFVSLARR RNVEPEDGIT KEQLKEFWEE MTDQNFDSRL
RIFFDMCDKN GDGMLTEDEV KEVIILSASA NKLAKLKGHA ATYASLIMEE LDPDDRGYIE
IWQLETLLRG MVSAQAPEKL KRTTSSLART MIPSRYRSPL KRHLSKTADF IHENWKRIWL
VTLWLVVNLA LFVFKFEQYK RRTSFQVMGY CVCVAKGAAE TLKLNMALIL LPVCRNTLTT
LRSTALNHVI PFDDNINFHK IMALSIAIAT AIHTLAHVTC DFPRLTSYPM DKFMATLGSN
FHYKQPTYSD LLQSIPGVTG ILMIIIMSFS FTLATHSFRR SVVKLPSPLH HLAGFNAFWY
AHHLLVLAYI LLVVHSYFIF LTREWYKKTT WMYLIVPVLF YACERTIRKV RENNYRVSIL
KASIYPGNVL SIHMKKPPGF KYKSGMYLFV KCPDVSPFEW HPFSITSAPG DDYLSVHIRT
LGDWTSELRN HFGKACEAQV TSKKATLTRL ETTVVADAQI EDTRFPRVYI DGPYGAPAQN
YKKYDILLLI GLGIGATPFI SILKDMLNNL KSNEEVESIH GSEIGSFKNN GPGRAYFYWV
TREQGSFEWF KGVMNDVAES DHSNVIEMHN YLTSVYEEGD ARSALIAMVQ SLQHAKNGVD
IVSGSRIRTH FARPNWRKVF SDLANAHRNS RIGVFYCGSP TLTKQLKELS KEFSQTTTTR
FHFHKENF
//
