ID K3XEQ5_SETIT Unreviewed; 785 AA.
AC K3XEQ5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE RecName: Full=Subtilisin-like protease {ECO:0008006|Google:ProtNLM};
GN Name=101753958 {ECO:0000313|EnsemblPlants:KQL06813};
GN ORFNames=SETIT_5G303900v2 {ECO:0000313|EMBL:RCV27179.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV27179.1};
RN [1] {ECO:0000313|EMBL:RCV27179.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL06813,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV27179.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV27179.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV27179.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL06813}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL06813};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; AGNK02003287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV27179.1; -; Genomic_DNA.
DR RefSeq; XP_004969820.1; XM_004969763.2.
DR AlphaFoldDB; K3XEQ5; -.
DR STRING; 4555.K3XEQ5; -.
DR MEROPS; S08.082; -.
DR EnsemblPlants; KQL06813; KQL06813; SETIT_000372mg.
DR GeneID; 101753958; -.
DR Gramene; KQL06813; KQL06813; SETIT_000372mg.
DR KEGG; sita:101753958; -.
DR eggNOG; ENOG502QRC5; Eukaryota.
DR HOGENOM; CLU_000625_4_6_1; -.
DR InParanoid; K3XEQ5; -.
DR OMA; EEHHHSY; -.
DR OrthoDB; 11910at2759; -.
DR Proteomes; UP000004995; Chromosome V.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02120; PA_subtilisin_like; 1.
DR CDD; cd04852; Peptidases_S8_3; 1.
DR Gene3D; 2.60.40.2310; -; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034197; Peptidases_S8_3.
DR InterPro; IPR010259; S8pro/Inhibitor_I9.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR InterPro; IPR045051; SBT.
DR InterPro; IPR041469; Subtilisin-like_FN3.
DR PANTHER; PTHR10795; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN; 1.
DR PANTHER; PTHR10795:SF562; SUBTILISIN-LIKE PROTEASE SBT5.5-RELATED; 1.
DR Pfam; PF17766; fn3_6; 1.
DR Pfam; PF05922; Inhibitor_I9; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..785
FT /note="Subtilisin-like protease"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010125640"
FT DOMAIN 34..108
FT /note="Inhibitor I9"
FT /evidence="ECO:0000259|Pfam:PF05922"
FT DOMAIN 147..611
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 414..488
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 680..782
FT /note="Subtilisin-like protease fibronectin type-III"
FT /evidence="ECO:0000259|Pfam:PF17766"
FT ACT_SITE 154
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 227
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 573
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 785 AA; 81676 MW; 0D064F67044C23B7 CRC64;
MRGAVAPPSL FLPLFLVLSS LSLVSSASGK QDQVYIVYLG GHAGAKVEEA ILEDHHALLR
SVKGSEEEAR ASLLYSYKHT LNGFAAILSR EEATELSERS EVVSAFRSEG RWAPHTTRSW
QFLGFEEGLK GPDGSDWLPS LDKSSGDVIV GVLDSGIWPE SKSFSDEGLG PVPARWKGVC
QSGESFSSSS CNRKIIGARY YLKAYEAHYK ALNTTYAFRS PRDHDGHGTH TASTVAGRTV
PGVSALGGFA AGTASGGAPL ARLAVYKVCW PIPGPNPNIE NTCFEADMLA AMDDAVGDGV
DVMSVSIGSS GAPMRFEDDG IAVGALHAAR RGVVVSCSGG NSGPKPATVS NLAPWMLTVG
ASSIDRAFDS PIKLGNGVGI MGQTVTPFQL PGNKPYPMVY AADAVVPGTP ANVSNQCLPN
SLSADKVRGK IVVCLRGSGL RVGKGLEVKR AGGAAILLGN PPASGSEVPV DAHILPGTAV
SAADAKTILG YINSSSSPTA VLVPSRTVVD VRPSPVMAQF SSRGPNVLEP NILKPDITAP
GLNILAAWSE ASSPTKLDGD HRVVQYNIMS GTSMSCPHVS AAVLLLKAAH PDWSAAAIRS
AIMTTATTNN AEGGPIMNGD GSVGGPMDYG SGHIRPNHAL DPGLVYDASY EDYLSFACAS
AGSQLDRSVP CPARPPPPYQ LNHPSVAVHG LNGTVTVRRT VTNVGSGEAR YAVAVAEPAG
VSVKVSPRRL RFARAGEKKV FTIRMEARAT GTSNGGVVRG QFVAGSYAWS DGVHVVRSPI
VVLVA
//
