ID K3XFW2_SETIT Unreviewed; 591 AA.
AC K3XFW2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00012256};
DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
GN Name=101774894 {ECO:0000313|EnsemblPlants:KQL07943};
GN ORFNames=SETIT_5G398800v2 {ECO:0000313|EMBL:RCV28351.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV28351.1};
RN [1] {ECO:0000313|EMBL:RCV28351.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL07943,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV28351.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV28351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV28351.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL07943}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL07943};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; AGNK02003391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV28351.1; -; Genomic_DNA.
DR RefSeq; XP_004970747.1; XM_004970690.2.
DR AlphaFoldDB; K3XFW2; -.
DR STRING; 4555.K3XFW2; -.
DR EnsemblPlants; KQL07943; KQL07943; SETIT_000781mg.
DR GeneID; 101774894; -.
DR Gramene; KQL07943; KQL07943; SETIT_000781mg.
DR KEGG; sita:101774894; -.
DR eggNOG; KOG2467; Eukaryota.
DR HOGENOM; CLU_022477_0_1_1; -.
DR InParanoid; K3XFW2; -.
DR OMA; SHMGRLF; -.
DR OrthoDB; 5358603at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000004995; Chromosome V.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR GO; GO:0070905; F:serine binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0046655; P:folic acid metabolic process; IBA:GO_Central.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IBA:GO_Central.
DR GO; GO:0006565; P:L-serine catabolic process; IBA:GO_Central.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR GO; GO:0046653; P:tetrahydrofolate metabolic process; IBA:GO_Central.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF7; SERINE HYDROXYMETHYLTRANSFERASE 7; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 135..538
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT REPEAT 463..479
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 64373 MW; A777402C4CC05255 CRC64;
MDLSRPASSD LSLGLHSHGP SHAHARVHAV AAPLRLFDDS EDAKPERLEG GEADGEREDE
EDGGDQHFSL LGHSLCVKRP RRAVNGGGGG GGETSSCSSS SAALRPAKRQ AMGEGSGPDL
ETRRAAVRAW GNQSLAEADP DVHALMEREL DRQVRGIELI ASENFVCRAV LDALGSHLTN
KYSEGLPGAR YYGGNQHIDA IERLCHERAL TAFGLDPACW GVNVQPYSCT SANLGVYTGL
LQPKDRIMGL EPPSGGHVSH GYYTPSGKKV SGASIFFESL SYKVNPQTGY IDYDKVEERA
MDFHPKILIC GGSSYPREWD FARMRLIADK CGAVLMCDMA HISGLVAAKE CRSPFDYCDV
VTSTTHKNLR GPRGGIIFFR KGKKLWKRGG SFSQGDEGEY DLEDKINFGV FPSMQGGPHN
NHIAALAITL KQVATPEYKA YIQQVKKNAQ ALASALLRRK CRLVTGGTDN HLVLWDLRTL
GLTGKIFEKV CEACHISINK TPIYGDNGSI SPGGVRIGTP AMTTRGCLED DFEAIAEFLI
RATQIASNVL REHGKQQKEF LRGLQNSKDV LELRNQVEVF ASQFAMPGFD I
//
