ID K3XUU0_SETIT Unreviewed; 1350 AA.
AC K3XUU0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL09879, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQL09879, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL09879,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQL09879}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL09879};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; AGNK02002288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 4555.K3XUU0; -.
DR EnsemblPlants; KQL09879; KQL09879; SETIT_005697mg.
DR Gramene; KQL09879; KQL09879; SETIT_005697mg.
DR eggNOG; KOG0597; Eukaryota.
DR HOGENOM; CLU_002453_1_1_1; -.
DR InParanoid; K3XUU0; -.
DR OMA; HAVEIMS; -.
DR Proteomes; UP000004995; Chromosome IV.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14002; STKc_STK36; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22983; PROTEIN KINASE RELATED; 1.
DR PANTHER; PTHR22983:SF6; SERINE_THREONINE-PROTEIN KINASE 36; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..256
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 260..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1350 AA; 148672 MW; DF6D33EC5A56C620 CRC64;
MGIEDYHVID LVGEGSFGKV YKGRRKYTRQ TVAMKFILKH GKTDKDIHNL RQEIEILRKL
KHENIIEMID AFETPQEFCV VTEFAQGELF EVLEDDKCLP EEQVQAIAKQ LVKALYYLHS
NRIIHRDMKP QNILIGKGSI VKLCDFGFAR AMSANTVVLR SIKGTPLYMA PELVREQPYN
HTADLWSLGV ILYELFVGQP PFYTNSVYAL IRHIVKDPVK YPDNMSSNFK SFLKGLLNKV
PQSRLTWPAL LEHPFVKDDS MESSIDTRTA PFEVKGSEDT RKKEEIQTPT NQSSQADPES
RITVTNRENA SDKPKGNRKL DVPMQATEDH YGSSTGADPE NCSPSPSGNM FLFWMYAISK
YFIAECTTLD KLEKASQTVK GANSILEDSE ALSTIVSPIK IWLTNPPSSP RELNIDGANQ
SLRIIKNLID ASSCQSYAAI DICMLLEFTN LIIRTKLSDA YGLVMKCLAI ARKLLDTNDE
LILSSYDRYW SSLYELYSQI LVSTVDPSGR IPRESTACLA LMLSRVISGL KASMSSEGPK
PVDKTLLKII DQSRRSQLLE LLCECLIASG SDIISGSTNM VPAACEACKA IWYLAHAVEI
MSISAQNFSF PFSNSWRHIH SIQEQGSMAD SNSTNLINIF VKSFLGSRPM QVAVYHCLHN
GLESAIHACL QLISRACLQN MSFCAIICRP WNLPSDVDAV EYGGDGTIVS DMFSLLSLCG
SILNKESKQN NNQKCKLSNP HALVVHCCLA LATIAACLKS GGESSASVIL TSSQKKQRSR
LSVLAHLSSV DDTVKSCLQP HCASAMLALS ALVSLENGGQ TRSSLCETAL ALFPRMATLH
TLLKLWLSDG SEALCRYNAG LLNLFGLRDG SIGLLETRLK WGGPLAIEQA CSVGIPQLLI
RLLTDGFSKE TSDGKDGSAS RSGLSPLGVV WTLSTLSQCL PGGIFREVLY RREQLKLLTD
LLSDVHLKAL AAWTGLGGGK RGVRELINSV VDILAFPFVA VQSSPNMPSA SASINSGFLL
NVASPGVRIG TENKEMLKTI EQNMPQYIQV LLEVGIPGCM LRCLDYVDME DLARPLAIVA
KMAGYRPLAL QLLKEGLLDP RRVAGLLEGP IAKETLLDFL MIVSDLARMS KDFYVPIDKA
GLVGFLKNFL SNEDPDIRAK ACSAIGNMCR HSSYFYSPLA ANKVIQLVVD RCSDPDKRTR
KFACFAVGNA AYHNDMLYEE LRRSIPQLTT LLLGPEEDKT KGNAAGALSN LVRNSDILCE
DIVSQGAIQA LLKMVGSYST VALSPSRRDA LTESPLRIVL FALRKMCDHA ICRNFLRSSE
LLPVIVHLRQ SPDPTISEYA SAIASRACQA
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