ID K3Y4M8_SETIT Unreviewed; 1710 AA.
AC K3Y4M8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=101777651 {ECO:0000313|EnsemblPlants:KQL00025};
GN ORFNames=SETIT_7G333500v2 {ECO:0000313|EMBL:RCV36634.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV36634.1};
RN [1] {ECO:0000313|EMBL:RCV36634.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL00025,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV36634.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV36634.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV36634.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL00025}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL00025};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; AGNK02004594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003534; RCV36634.1; -; Genomic_DNA.
DR RefSeq; XP_004977646.1; XM_004977589.3.
DR STRING; 4555.K3Y4M8; -.
DR EnsemblPlants; KQL00025; KQL00025; SETIT_009166mg.
DR GeneID; 101777651; -.
DR Gramene; KQL00025; KQL00025; SETIT_009166mg.
DR eggNOG; KOG0985; Eukaryota.
DR HOGENOM; CLU_002136_0_0_1; -.
DR InParanoid; K3Y4M8; -.
DR OMA; HTRVMDY; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000004995; Chromosome VII.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IBA:GO_Central.
DR GO; GO:0032051; F:clathrin light chain binding; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IBA:GO_Central.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 2.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 344..367
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1710 AA; 193649 MW; E96591684C63AB6A CRC64;
MAAANAPIAM REALTLTSLG IAPQFVTFTH VTMESEKYIC VRETSPQNSV VIIDMAMPMQ
PLRRPITADS ALMNPNTRIL ALKAQIPGTT QDHLQIFNIE AKTKIKSHQM PEQVVFWKWI
TPKLVGLVTQ TSVYHWSIEG DSEPTKMFDR TANLANNQII NYRCDPAEKW LVLIGIAPGA
PERPQLVKGN MQLFSVDQQR SQALEAHAAS FATFKVVGNE NPSTLICFAS KTTNAGQITS
KLHVIELGAQ PGKPGFSKKQ ADLFFPPDFQ DDFPVAMQVS QKYGLIYVIT KLGLLFVYDL
ETAAAVYRNR ISPDPIFLTA ESSSTGGFYA INRRGQVLHA TVNDATVVPF VSGQLNNLEL
AVNLAKRANL PGAENLVVQR FQELFAQTKY KEAAELAAES PQGLLRTPET VAKFQSVPVQ
AGQTPPLLQY FGTLLTRGKL NAFESLELSR LVVNQNKKNL LENWLAEDKL ECSEELGDLV
KTVDNDMALK IYIKARATPK VVAAFAERRE FDKILIYSKQ VGYTPDYLFL LQTILRTDPQ
GAVNFALMMS QMEGGCPVDY NTITDLFLQR NMIREATAFL LDVLKPNLPE HAFLQTKVLE
INLVTYPNVA DAILANGMFS HYDRPRIAQL CEKAGLYLRA LQHYSELPDI KRVMVNTHAI
EPQALVEFFG TLSREWALEC MKDLLVVNLR GNLQIVVQAA KEYSEQLGVD ACIKLFEQFK
SYEGLYFFLG SYLSSSEDPD IHFKYIEAAA RTGQIKEVER VTRESNFYDA EKTKNFLMEA
KLPDARPLIN VCDRFGFVPD LTHYLYTNNM LRYIEGYVQK VNPGNAPLVV GQLLDDECPE
DFIKGLILSV RSLLPVEPLV DECEKRNRLR LLTQFLEHLV SEGSQDVHVH NALGKIIIDS
NNNPEHFLTT NPFYDSRVVG KYCEKRDPTL AVVAYRRGQC DDELINVTNK NSLFKLQARY
VVERMDGDLW DKVLQPENEY RRQLIDQVVS TALPESKSPE QVSAAVKAFM TADLPHELIE
LLEKIVLQNS AFSGNFNLQN LLILTAIKAD PSRVMDYVNR LDNFDGPAVG EVAVEAQLYE
EGFAIFKKFN LNVQAVNVLL DNIRSIERAE EFAFRVEEDA VWSQVAKAQL REGLVSEAIE
SFIRADDAAH FLDVIHAAEE ANVYNDLVKY LLMVRQKARE PKVDGELIFA YAKIDRLSDI
EEFILMPNVA NLQNVGDRLY DEELYEAAKI IYAFISNWAK LAVTLVKLKQ FQGAVDAARK
ANSAKTWKEV CFACVDAEEF RLAQICGLNI IVQVDDLEEV SEYYQNRGCF NELIALMESG
LGLERAHMGI FTELGVLYAR YRYEKLMEHI KLFSTRLNIP KLIRACDEQQ HWKELTYLYI
QYDEFDNAAT TIMNHSPDAW DHMQFKDVCV KVANVELYYK AVHFYLQEHP DLINDMLNVL
ALRLDHTRVV DIMRKAGQLH LVKPYMVAVQ SNNVSAVNEA LNELYVEEED YERLRESVDM
HDNFDQIGLA QKLEKHELLE MRRIAAYIYK KAGRWKQSIA LSKKDNMYKD CMETCSQSGD
RELSEDLLVY FIEQGKKECF ASCLFICYDL IRPDVALELA WMNNMIDFAF PYLLQFIREY
SSKVDDLVKD KIESQNEERA KEKEEKDLVA QQNMYAQLLP LALPAPPMPG MGGPPPPMGG
MGMPPMGGMG MPPMGPGPMP AFGMPPMGSY
//
