ID K3YRJ0_SETIT Unreviewed; 528 AA.
AC K3YRJ0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN Name=101782853 {ECO:0000313|EnsemblPlants:KQL28523};
GN ORFNames=SETIT_1G069500v2 {ECO:0000313|EMBL:RCV05265.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV05265.1};
RN [1] {ECO:0000313|EMBL:RCV05265.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL28523,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV05265.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV05265.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV05265.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL28523}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL28523};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC {ECO:0000256|ARBA:ARBA00005176}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
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DR EMBL; AGNK02000101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003528; RCV05265.1; -; Genomic_DNA.
DR RefSeq; XP_004951749.1; XM_004951692.3.
DR AlphaFoldDB; K3YRJ0; -.
DR STRING; 4555.K3YRJ0; -.
DR EnsemblPlants; KQL28523; KQL28523; SETIT_016884mg.
DR GeneID; 101782853; -.
DR Gramene; KQL28523; KQL28523; SETIT_016884mg.
DR KEGG; sita:101782853; -.
DR eggNOG; KOG2451; Eukaryota.
DR HOGENOM; CLU_005391_0_0_1; -.
DR InParanoid; K3YRJ0; -.
DR OMA; VNGNWID; -.
DR OrthoDB; 3078548at2759; -.
DR UniPathway; UPA00733; -.
DR Proteomes; UP000004995; Chromosome I.
DR ExpressionAtlas; K3YRJ0; baseline.
DR GO; GO:0004777; F:succinate-semialdehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IBA:GO_Central.
DR CDD; cd07103; ALDH_F5_SSADH_GabD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR InterPro; IPR010102; Succ_semiAld_DH.
DR NCBIfam; TIGR01780; SSADH; 1.
DR PANTHER; PTHR43353; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43353:SF5; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036492};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT DOMAIN 63..522
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 299
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 333
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 528 AA; 56208 MW; B2640270B8102883 CRC64;
MAMAIGMMTM RRAAALGARH ILAASSSSRV VPLRHMSADA GAAMEKIRAA GLLRTQGLIA
GQWVDAYDGK TIEVQNPATG EVLASVSCMG SRETSDAIAS AHSTFYSWSK LTANERSKAL
RKWYDLIIAH KEELALLMTL EQGKPMKEAL GEVNYGASFI EYFAEEAKRI YGDIIPPTLS
DRRLLVLKQP VGVVGAITPW NFPLAMITRK VGPALACGCT VVVKPSEFTP LTALAAADLA
LQAGIPAGAL NVVMGNAPEI GDALLQSTQV RKITFTGSTA VGKKLMAGSA DTVKKVSLEL
GGNAPCIVFD DADIDVAVKG SLAAKFRNSG QTCVCANRIL VQEGIYEKFA SAFIKAVQSL
QVGNGLEEST SQGPLINEAA VQKVEKFIND ATSKGANVML GGKRHSLGMT FYEPTVVGNV
SNDMLLFREE VFGPVAPLIP FKTEEEAIHL ANDTNAGLAA YIFTRSIPRS WRVSESLEYG
LVGVNEGIIS TEVAPFGGVK QSGLGREGSK YGVDEYLELK YICMGNMG
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