ID K3Z4D4_SETIT Unreviewed; 666 AA.
AC K3Z4D4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=NAD(P)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=101768755 {ECO:0000313|EnsemblPlants:KQL13594};
GN ORFNames=SETIT_3G084800v2 {ECO:0000313|EMBL:RCV15776.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL13594, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV15776.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL13594,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV15776.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV15776.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV15776.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL13594}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL13594};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; AGNK02001462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003530; RCV15776.1; -; Genomic_DNA.
DR RefSeq; XP_004960685.1; XM_004960628.3.
DR AlphaFoldDB; K3Z4D4; -.
DR STRING; 4555.K3Z4D4; -.
DR EnsemblPlants; KQL13594; KQL13594; SETIT_021402mg.
DR GeneID; 101768755; -.
DR Gramene; KQL13594; KQL13594; SETIT_021402mg.
DR KEGG; sita:101768755; -.
DR eggNOG; KOG0747; Eukaryota.
DR HOGENOM; CLU_026813_1_0_1; -.
DR InParanoid; K3Z4D4; -.
DR OrthoDB; 5486426at2759; -.
DR Proteomes; UP000004995; Chromosome III.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR43000:SF52; SALMON SILKS1; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT DOMAIN 11..316
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
FT DOMAIN 380..552
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 666 AA; 74993 MW; 500DCFCCD328FCFD CRC64;
MATAYKPKNI LITGAAGFIA SHVAIRITKK YPDYKIVVLD KLDYCSNLKN LLPVSSSPNF
KFVKGDIASA DLVNFLLVTE NIDTIMHFAA QTHVDNSFGN SFEFTKNNIY GTHVLLEACK
ITGQIKRFIH VSTDEVYGET DEDAVVGNKE ASQLLPTNPY AATKAGAEML VMAYGRSYGL
PVITTRGNNV YGPNQFPEKL IPKFILLAMR GEPLPIHGDG TNVRSYLYCE DVAEAFEVIL
HHGEVGHVYN IGTKRERTVI DVAKDVCKLF NLEADKVIMF VENRPFNDQR YFLDDEKLKS
LGWAERTPWE EGLKKTMEWY VANSDYWGDV SGALLPHPRT LMMPGYEGSE EIKGILSQFN
NIQTKVASTS DSAPETHAFK FLIYGRTGWI GGLLGKICEK QGIPYEYGKG RLQERSSLIL
DIQTIKPTHV FNAAGVTGRP NVDWCESHKP DTIRTNVVGT LTLADVCREH GLLMINYATG
CIFEYDACHP EGSGIGFKEE DTPNFTGSFY SKTKAMVEEL LKEYENVCTL RVRMPISSDL
SNPRNFVTKI SRYNKVVNIP NSMTILDELL PISVEMAKRN LRGIYNFTNP GVVSHNEILE
MYKQYIHPSF KWTNFNLEEQ AKVIIAPRSN NEMDASKLKK EFPELLSIKD SLIKYVFEPN
QKLPIN
//
