ID K3ZH29_SETIT Unreviewed; 1016 AA.
AC K3ZH29;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752, ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=101785066 {ECO:0000313|EnsemblPlants:KQK94760};
GN ORFNames=SETIT_8G136500v2 {ECO:0000313|EMBL:RCV38367.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV38367.1};
RN [1] {ECO:0000313|EMBL:RCV38367.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK94760,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV38367.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV38367.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV38367.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK94760}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK94760};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; AGNK02004985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003535; RCV38367.1; -; Genomic_DNA.
DR RefSeq; XP_004979371.1; XM_004979314.2.
DR AlphaFoldDB; K3ZH29; -.
DR SMR; K3ZH29; -.
DR STRING; 4555.K3ZH29; -.
DR EnsemblPlants; KQK94760; KQK94760; SETIT_025881mg.
DR GeneID; 101785066; -.
DR Gramene; KQK94760; KQK94760; SETIT_025881mg.
DR KEGG; sita:101785066; -.
DR eggNOG; KOG1959; Eukaryota.
DR HOGENOM; CLU_004690_2_0_1; -.
DR InParanoid; K3ZH29; -.
DR OMA; WIYQINR; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000004995; Chromosome VIII.
DR GO; GO:0004559; F:alpha-mannosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 23..1016
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5010127785"
FT DOMAIN 356..430
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1016 AA; 113547 MW; 686DEA4BA35AF9B7 CRC64;
MGPVRLALLL AAAVALAAVG EAVYIPYNTS AGVVAGKLNV HVVPHTHDDV GWLKTVDQYY
VGSNNSIQGA CVQNVLDSLI PALLKDENRK FVYVEQAFFQ RWWRNQNDMI KDTVKGLISS
GRLELINGGM CMHDEATVHY IDMIDQTTLG HKFVKEEFGQ IPRIGWQIDP FGHSAVQAYL
LGAEVGFDAF YFFRIDYQDR DTRKGTKELE VVWRGSKSFG SSADIFAGIF PKNYEPPPGG
FYFEVNDDSP VVQDDPLLFD YNVEERVNDF VAAALAQANI TRTNHIMFTM GTDFKYQYAE
SWFRNMDKLI HYVNKHGLIN ALYSTPSIYT DAKYAANEQW PLKTNDFFPY ADNPNAYWTG
YFTSRPALKR YVRMMSGYYL AARQLEFFKG KSKSGPTTDY LGDALALAQH HDAVTGTEKQ
HVANDYAKRL SIGYTQAQEL VSTSLACLTE SGSKSRCSTP TTKFSQCLLL NVTFCPPSEM
DFSEGKSLVV LVYNSLGWKR EDVLRVPVFS DSIVVHDSEG KEIESQLLPI ASASQNIRDQ
HVKAYLGTTP GAKPKFWLAF PVSVPPLGFN TYFVSSTKKS ASVSSKSTLY SSQGSKDNLQ
VGQGNLKLQY NAAGALSLYS DRKTLIEANF EQKYKYYIGQ DGNGSDPQAS GAYIFRPNGT
VPIKTDGQVP LTVLRGPILD EVHHQINSWI YQITRVYKGK DYVETEFIVG PIPIDDGNGK
EIATEIVTNM ATNKTFYTDS SGRDFIKRIR DYRSEWKIEV HQPIAGNYYP VNLGIYVEDG
SKELSVLVDR SVGGSSIKDG QIELMLHRRL LHDDGRGVAE ALNETVCVDK QCEGLIIEGK
YYLKIDPQGE GARWRRTFGQ EIYSPLLLAF SEQDGGNWAN SHVPKFSAMD PTYSLPDNVA
LLTLQELEDG TVLLRFAHLY EAGEHKDLSA LASVNLKRVF PDKKIGKIIE TSLSANQERA
AMEKKRLKWK VQGPPADKVV RGGPVDPSKL VVELGPMEIR TFIVSFDRSI SGKQLL
//
